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Flavonoid-drug interactions: effects of flavonoids on ABC transporters.

机译：类黄酮-药物相互作用：类黄酮对ABC转运蛋白的影响。

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摘要

Flavonoids are present in fruits, vegetables and beverages derived from plants (tea, red wine), and in many dietary supplements or herbal remedies including Ginkgo Biloba, Soy Isoflavones, and Milk Thistle. Flavonoids have been described as health-promoting, disease-preventing dietary supplements, and a high intake of flavonoids has been associated with a reduced risk of cancer, cardiovascular diseases, osteoporosis and other age-related degenerative diseases. Due to an increased public interest in alternative medicine and disease prevention, the use of herbal preparations containing high doses of flavonoids for health maintenance has become very popular, raising the potential for interactions with conventional drug therapies. This review will summarize the current literature regarding the interactions of flavonoids with ATP-binding cassette (ABC) efflux transporters, mainly P-glycoprotein, MRP1, MRP2 and BCRP and discuss the potential consequences for flavonoid-drug transport interactions.
机译：类黄酮存在于源自植物的水果，蔬菜和饮料（茶，红酒）中，并且在许多饮食补品或草药中，包括银杏叶，大豆异黄酮和水飞蓟。类黄酮已被描述为促进健康，预防疾病的膳食补充剂，而大量摄入类黄酮可降低癌症，心血管疾病，骨质疏松症和其他与年龄有关的变性疾病的风险。由于公众对替代药物和疾病预防的兴趣增加，使用含有高剂量类黄酮的草药制剂来维持健康已变得非常流行，这增加了与常规药物疗法相互作用的可能性。这篇综述将总结有关类黄酮与ATP结合盒（ABC）外排转运蛋白（主要是P-糖蛋白，MRP1，MRP2和BCRP）相互作用的最新文献，并讨论类黄酮-药物转运相互作用的潜在后果。

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