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首页> 外文期刊>Life sciences >Effect of chitooligosaccharides on calcium bioavailability and bone strength in ovariectomized rats.
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Effect of chitooligosaccharides on calcium bioavailability and bone strength in ovariectomized rats.

机译：壳寡糖对去卵巢大鼠钙生物利用度和骨强度的影响。

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Chitosan polymer with deacetylation degree of 93% was hydrolyzed with an endo-type chitosanase (35,000 U/g protein) with substrate to enzyme ratio of 1 to 1.5 for 18 h in a batch reactor, and then the resultant hydrolysates were fractionated into four different molecular weights using an ultrafiltration (UF) membrane reactor system. An in vitro study elucidated that four kinds of chitooligosaccharides (COSs) could efficiently inhibit the formation of insoluble calcium salts in the neutral pH. In vivo effects of COSs on Ca bioavailability were further studied in the osteoporosis modeling rats induced by ovariectomy and concurrent low calcium intake. During the experimental period corresponding to the menopause with the osteoporosis disease, calcium retention was increased and bone turnover was decreased by COS IV supplementation in the ovariectomized (OVX) rats. After the low Ca diet, COS IV diet including both normal level of calcium and vitamin D significantly decreased calcium loss in feces and increased calcium retention compared to the control diet. The levels of femoral total calcium, bone mineral density (BMD), and femoral strength were also significantly increased by the COS IV diet in a similar level to those of CPP diet group. In the present study, the results proved the beneficial effects of low molecular chitooligosaccharide (COS IV) in preventing negative mineral balance.
机译：将脱乙酰度为93％的壳聚糖聚合物在分批反应器中用底物与酶之比为1：1.5的内切型壳聚糖酶（35,000 U / g蛋白质）水解18 h，然后将所得的水解产物分馏成四个不同的使用超滤（UF）膜反应器系统测定分子量一项体外研究表明，四种壳寡糖（COSs）可以有效抑制中性pH下不溶性钙盐的形成。在卵巢切除术并发低钙摄入引起的骨质疏松模型大鼠中，进一步研究了COS对Ca生物利用度的体内影响。在与骨质疏松症更年期相对应的实验期间，通过卵巢切除（OVX）大鼠中的COS IV补充，钙保留量增加，骨转换减少。在低钙饮食之后，与正常饮食相比，同时包含正常钙水平和维生素D的COS IV饮食显着减少了粪便中的钙流失并增加了钙保留。 COS IV饮食组的股总钙，骨矿物质密度（BMD）和股骨强度也显着增加，与CPP饮食组相似。在本研究中，结果证明了低分子壳寡糖（COS IV）在防止负矿物质平衡方面的有益作用。

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