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Production of lysophosphatidic acid by spontaneously hypertensive rats and wistar kyoto rats

机译：自发性高血压大鼠和Wistar京都大鼠产生溶血磷脂酸

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Lysophosphatidic acid has been identified as a vasopressor principle in incubated mammalian plasma and sera, and shown to be generated extracellulary by lysophospholipase D-like activity. In this study, we monitored the time course of changes in the major phospholipid fractions during incubation of plasma, and found that polyunsaturated lysophosphatidic acids accumulate more rapidly than saturated lysophosphatidic acids at expense of the corresponding lysophosphatidylcholines. We compared the phospholipase activities for producing bioactive LPA in age-matched spontaeneously hypertensive rats and Wistar Kyoto rats. The lysophosplipase D activity in rat plasma was found to be independent of strain and age. We suggest that lysophospholipase D functions in rat for persistent production of bioactive LPA in the circulation throughout life. However, our finding that production of LPA in spontaenously hypertensive rats was not greater than that in Wistar Kyoto rats does not seen to support the idea that increased production of LPA is involved in the pathogenesis of hypertension.
机译：溶血磷脂酸已被确定为在培养的哺乳动物血浆和血清中的血管升压药原理，并显示是通过溶血磷脂酶D样活性在细胞外产生的。在这项研究中，我们监测了血浆孵育过程中主要磷脂组分的变化的时程，发现多不饱和溶血磷脂酸的积累速度比饱和溶血磷脂酸要快，但会消耗相应的溶血磷脂酰胆碱。我们比较了在年龄匹配的自发性高血压大鼠和Wistar Kyoto大鼠中产生生物活性LPA的磷脂酶活性。发现大鼠血浆中的溶血磷脂酶D活性与品系和年龄无关。我们建议溶血磷脂酶D在大鼠中发挥作用，在整个生命周期中持续产生生物活性LPA。但是，我们的发现自发性高血压大鼠中LPA的产生不大于Wistar Kyoto大鼠中的LPA的发现，未发现支持LPA产生增加与高血压的发病机理有关的观点。

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