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首页> 外文期刊>Life sciences >The specificity of platelet glutamate receptor supersensitivity in psychotic disorders.
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The specificity of platelet glutamate receptor supersensitivity in psychotic disorders.

机译：在精神病性疾病中血小板谷氨酸受体超敏性的特异性。

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Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia, and supersensitivity of platelet NMDA receptors has been reported in schizophrenia. The aim of this study was to examine the platelet glutamate receptor sensitivity in patients with schizophrenia (n=12), mania with psychotic features (n=10) and depression with psychotic features (n=10) and matched controls (n=12) in order to assess if this is a marker of schizophrenia or occurs in other psychotic conditions. Glutamate receptor sensitivity was assessed using the intracellular calcium response to glutamate measured with spectrofluorometry. The percentage response of the schizophrenic and depressed psychotic subjects to glutamate stimulation was significantly greater than control subjects (p<0.005). The mania with psychotic features group was not significantly different to controls. This data suggests that platelet glutamate receptors may be supersensitive in schizophrenia and depression with psychotic features. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia and depression with psychotic features.
机译：精神分裂症的发病机理涉及低谷氨酸能功能，并且在精神分裂症中已经报道了血小板NMDA受体的超敏性。这项研究的目的是检查精神分裂症（n = 12），精神病性躁狂症（n = 10）和精神病性抑郁症（n = 10）和相匹配的对照组（n = 12）患者的血小板谷氨酸受体敏感性为了评估这是否是精神分裂症的标志物或在其他精神病状态下发生。使用荧光分光光度法测量的细胞内钙对谷氨酸的反应来评估谷氨酸受体的敏感性。精神分裂症和抑郁的精神病患者对谷氨酸刺激的百分比反应显着大于对照组（p <0.005）。精神病性躁狂症组与对照组无显着差异。该数据表明血小板谷氨酸受体在精神分裂症和具有精神病特征的抑郁症中可能是超敏感的。此外，血小板可能是精神分裂症和精神病性抑郁症中谷氨酸功能的可能外周标志物。

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