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首页> 外文期刊>Life sciences >Exchange of endogenous selenium for dietary selenium as 82Se-enriched selenite in brain, liver, kidneys and testes.
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Exchange of endogenous selenium for dietary selenium as 82Se-enriched selenite in brain, liver, kidneys and testes.

机译：将内源硒交换为膳食硒，使大脑，肝脏，肾脏和睾丸中的硒富含82硒。

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Male Wistar rats were fed a diet containing selenium (Se) in the form of 82Se-enriched selenite at the adequate concentration of 0.2 microg Se/g diet, i.e. a Se-deficient diet (<0.03 microg Se/g) fortified with 82Se-enriched selenite, from 5 weeks of age for 20 days, and the systemic disposition of the labelled Se and exchange of endogenous naturally occurring Se for the labelled Se were monitored in four organs. Features characteristic of each organ in terms of Se metabolism were revealed by plotting the disposition of 82Se and exchange of endogenous Se for 82Se against the number of days of feeding 82Se-selenite. Labelled Se amounted to 83.7, 80.8, 73.2 and 41.9% of the total Se in the liver, kidneys, testes and brain, respectively, after feeding 82Se-selenite for 20 days, suggesting that the disposition and exchange were most efficient in the liver but least efficient in the brain. However, when the weight gain of the four organs during the feeding period was taken into consideration, the apparent higher exchange was concluded to be caused by weight gain, i.e., more efficient uptake of the labelled Se by proliferating cells than non-proliferating cells in the liver, kidneys and testes. On the other hand, the uptake and exchange in non-proliferating cells were greater in the brain than in the other organs, especially in the late observation period. The relative metabolic turnover rates of selenoproteins were shown to be easy to determine from the relative exchange rates of endogenous Se for exogenous Se in the distribution profiles of Se obtained by the HPLC-ICP MS method.
机译：给雄性Wistar大鼠喂食含硒（Se）的饮食，硒的形式为富含82Se的亚硒酸盐，其浓度为0.2微克Se / g饮食，即以82Se-强化的无硒饮食（<0.03 microg Se / g）。从四个星期开始，从5周龄开始持续20天的富含亚硒酸盐的富集，以及标记硒的系统性处置以及内源天然硒的交换。通过绘制82Se的分布和内源性Se交换82Se相对于饲喂82Se-硒矿的天数，揭示了每个器官的硒代谢特征。饲喂82 Se-硒矿20天后，肝脏，肾脏，睾丸和脑中标记的硒分别占总硒的83.7％，80.8、73.2和41.9％，这表明在肝脏中处置和交换最有效，但是在大脑中效率最低。但是，考虑到进食期间四个器官的体重增加，可以得出结论认为明显的更高交换是由体重增加引起的，即，相比于非增殖细胞，增殖细胞更有效地摄取了标记的硒。肝脏，肾脏和睾丸。另一方面，大脑中非增殖细胞的摄取和交换比其他器官要大，尤其是在观察后期。在通过HPLC-ICP MS方法获得的Se分布图中，可以很容易地根据内源Se与外源Se的相对交换速率确定硒蛋白的相对代谢转换速率。

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