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首页> 外文期刊>Life sciences >In vivo lipolysis in adipose tissue from two anatomical locations measured by microdialysis.
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In vivo lipolysis in adipose tissue from two anatomical locations measured by microdialysis.

机译：通过微透析从两个解剖位置对脂肪组织进行体内脂解。

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摘要

In this study, the difference in lipolytic response in inguinal subcutaneous and epididymal adipose tissues of male Sprague-Dawley rats was assessed in vivo by microdialysis. Probes were perfused with Ringer solution in which increasing concentrations of isoproterenol (10(-7) - 10(-4) mol/L) were added. Glycerol release, expressed as extracellular glycerol concentration, was used as lipolytic index. The effect of isoproterenol on local blood flow was investigated using the ethanol technique. No differences were found in the interstitial glycerol concentration between both adipose tissues under basal conditions. When isoproterenol was perfused, a dose-response increase in glycerol production was induced in both tissues. Interstitial glycerol concentration from epididymal adipose tissue was higher than that of inguinal subcutaneous depot at all isoproterenol concentrations. No vasodilatory effect of isoproterenol was found. These results suggest that epididymal adipose tissue is more responsive in vivo to beta-adrenergic lipolysis stimulation than is subcutaneous fat pad from the inguinal region.
机译：在这项研究中，通过微透析在体内评估了雄性Sprague-Dawley大鼠腹股沟皮下和附睾脂肪组织中脂解反应的差异。用林格溶液灌注探针，其中添加浓度不断增加的异丙肾上腺素（10（-7）-10（-4）mol / L）。以细胞外甘油浓度表示的甘油释放用作脂解指数。使用乙醇技术研究了异丙肾上腺素对局部血流的影响。在基础条件下，两个脂肪组织之间的间质甘油浓度没有发现差异。当灌注异丙肾上腺素时，在两个组织中都诱导了甘油产生的剂量反应增加。在所有异丙肾上腺素浓度下，附睾脂肪组织的间质甘油浓度均高于腹股沟皮下贮库。没有发现异丙肾上腺素的血管舒张作用。这些结果表明，附睾脂肪组织在体内对β-肾上腺素脂解刺激的反应比腹股沟区域的皮下脂肪垫更敏感。

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