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首页> 外文期刊>Life sciences >Comparison between the effects of pentobarbital or ketamineitrous oxide anesthesia on metabolic and endothelial components of coronary reactive hyperemia
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Comparison between the effects of pentobarbital or ketamineitrous oxide anesthesia on metabolic and endothelial components of coronary reactive hyperemia

机译：戊巴比妥或氯胺酮/一氧化二氮麻醉对冠状动脉反应性充血的代谢和内皮成分的影响比较

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Barbiturates induce reduction of myocardial contractility and metabolism, whereas ketamine exerts a sympathomimetic effect that can mask its direct depressant effect on contractility. However, it is un clear whether barbiturates, which interfere with the cytochrome P-450 pathway, or ketamine, which inhibits nitric oxide synthesis, also alter the responsiveness of the coronary vessels to vasodilator stimuli. We hypothesized that the parameters of coronary reactive hyperemia (CRH), which reflect both the degree of myocardial metabolism and vascular reactivity, could be modified by the type of anesthesia used. In two groups of goats, anesthesia was induced either using ketamine plus nitrous oxide or pentobarbital alone. To record coronary flow an electromagnetic flow-probe was placed around the left circumflex coronary artery. In the ketamine group(n= 14) and in the pentobarbital group (n = 16) CRH was studied using the indices of myocardial metabolism and vascular dilator responsiveness. In the pentobarbital group all of the indices of myocardial metabolism were lower than in the ketamine group (i.e, the excess to debt flow ratio was 2.3+/-0.8 vs. 4.6+/-2.4: p<0.001). Yet, some indices of vascular responsiveness (time derivative of coronary flow and the peak to basal flow ratio) were not different in the two groups. Moreover, the duration of the reactive hyperemia was shorter in the ketamine than in the pentobarbital group (118+/-47 vs.153+/-45 s, p<0.05). It is suggested that pentobarbital decreases the indices of CRH related to metabolic activity, whereas ketamine reduces the duration of the hyperemic response, which suggests an impairment of endothelial function. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 41]
机译：巴比妥类药物可降低心肌的收缩力和新陈代谢，而氯胺酮具有拟交感神经作用，可掩盖其对收缩力的直接抑制作用。但是，尚不清楚会干扰细胞色素P-450途径的巴比妥类药物或抑制一氧化氮合成的氯胺酮是否也会改变冠状血管对血管扩张剂的反应性。我们假设可以通过使用的麻醉类型来修改反映心肌代谢程度和血管反应性的冠状动脉反应性充血（CRH）参数。在两组山羊中，使用氯胺酮加一氧化二氮或单独使用戊巴比妥诱导麻醉。为了记录冠状动脉血流，将电磁血流探针置于左旋支冠状动脉周围。在氯胺酮组（n = 14）和戊巴比妥组（n = 16）中，使用心肌代谢和血管扩张剂反应指数研究CRH。戊巴比妥组的所有心肌代谢指标均低于氯胺酮组（即超额债务流动比率为2.3 +/- 0.8对4.6 +/- 2.4：p <0.001）。然而，两组的某些血管反应性指标（冠状动脉血流时间导数和峰基流量比）没有差异。此外，氯胺酮的反应性充血持续时间比戊巴比妥组短（118 +/- 47 vs.153 +/- 45 s，p <0.05）。提示戊巴比妥可降低与代谢活性相关的CRH指数，而氯胺酮可减少充血反应的持续时间，这提示内皮功能受损。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：41]

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