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首页> 外文期刊>Life sciences >Inhibition of human immunodeficiency virus type 1 reverse transcriptase, protease and integrase by bovine milk proteins.
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Inhibition of human immunodeficiency virus type 1 reverse transcriptase, protease and integrase by bovine milk proteins.

机译：牛乳蛋白对人类1型免疫缺陷病毒的逆转录酶，蛋白酶和整合酶的抑制作用。

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摘要

Different proteins have been isolated from bovine milk including lactoferrin, lactoperoxidase, glycolactin, angiogenin-1, lactogenin, alpha-lactalbumin, lactoglobulin and casein. These proteins have been assayed for inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, protease and integrase, enzymes crucial to the HIV-1 life cycle. It was found that different milk proteins inhibited the three aforementioned HIV enzymes to different extents. Lactoferrin strongly inhibited HIV-1 reverse transcriptase but only slightly inhibited HIV-1 protease and integrase. On the other hand, alpha-lactalbumin, beta-lactoglobulin and casein inhibited HIV-1 protease and integrase to an appreciable extent but did not inhibit HIV-1 reverse transcriptase. Glycolactin and angiogenin-1 suppressed the activity of HIV-1 reverse transcriptase by a moderate extent but more powerfully inhibited HIV-1 protease and integrase. In comparison with the other milk proteins glycolactin was a strong inhibitor of HIV-1 protease and integrase and a moderate inhibitor of HIV-1 reverse transcriptase. Lactogenin was a strong inhibitor of HIV-1 integrase, a moderate inhibitor of HIV-1 reverse transcriptase and a weak inhibitor of HIV-1 protease.
机译：从牛乳中已分离出不同的蛋白质，包括乳铁蛋白，乳过氧化物酶，甘醇肌动蛋白，血管生成素-1，乳生成素，α-乳白蛋白，乳球蛋白和酪蛋白。已对这些蛋白质的抗1型人类免疫缺陷病毒（HIV-1）逆转录酶，蛋白酶和整合酶（对HIV-1生命周期至关重要的酶）具有抑制活性。发现不同的乳蛋白在不同程度上抑制了上述三种HIV酶。乳铁蛋白强烈抑制HIV-1逆转录酶，但仅轻微抑制HIV-1蛋白酶和整合酶。另一方面，α-乳清蛋白，β-乳球蛋白和酪蛋白抑制HIV-1蛋白酶并整合到一定程度，但不抑制HIV-1逆转录酶。糖皮质激素和血管生成素-1适度地抑制了HIV-1逆转录酶的活性，但更有效地抑制了HIV-1蛋白酶和整合酶。与其他乳蛋白相比，糖化肌动蛋白是HIV-1蛋白酶和整合酶的强抑制剂，是HIV-1逆转录酶的中度抑制剂。乳原蛋白是HIV-1整合酶的强抑制剂，HIV-1逆转录酶的中度抑制剂，HIV-1蛋白酶的弱抑制剂。

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