• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Airway hyperresponsiveness to bronchoconstrictor challenge after wood smoke exposure in guinea pigs
【24h】

Airway hyperresponsiveness to bronchoconstrictor challenge after wood smoke exposure in guinea pigs

机译：豚鼠暴露于木烟后气道对支气管收缩刺激的反应过度

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prior airway exposure to wood smoke induces an increase in airway responsiveness to subsequent smoke inhalation in guinea pigs (Life Sci. 63: 1513, 1998; 66: 971,2000). To further characterize this airway hyperreactivity, we investigated and compared the airway responsiveness to bronchoconstrictor challenge before and 30 min after sham air exposure or wood smoke exposure in anesthetized and artificially ventilated guinea pigs. Various doses of substance P (0.8-6.4 mug/kg), capsaicin (0.2-3.2 mug/kg), prostaglandin F-2 alpha (30-3000 mug/kg),histamine (1-8 mug/kg), or acetylcholine (5-20 mug/kg) were intravenously injected at 2-min intervals in successively increasing doses to obtain the dose required to provoke a 200% increase in baseline total lung resistance (ED200). Wood smoke exposure significantly lowered the ED200 of substance P, capsaicin, and prostaglandin F-2 alpha whereas sham air exposure failed to do so. Furthermore, wood smoke exposure did not significantly alter the ED200 of histamine or acetylcholine. Pretreatment with phosphoramidon (2 mg/kg), an inhibitor of the neutral endopeptidase (the major degradation enzyme of substance P), before smoke exposure did not significantly affect the smoke-induced reduction in ED200 of substance P. Sectioning both cervical vagi before smoke exposure did not significantly alter the smoke-induced reduction in ED200 of capsaicin or prostaglandin F-2 alpha. These results suggest that airway exposure to wood smoke acutely produces airway hyperresponsiveness to substance P, capsaicin, and prostaglandin F-2 alpha, but not to histamine or acetylcholine. Since the combination of phosphoramidon and wood smoke exposure did not result in an additive potentiation of smoke-induced airway hyperresponsiveness to substance Pit is suggested that an inhibition of the degradation enzyme of substance P may contribute to this increase in airway reactivity. Furthermore, vagally-mediated bronchoconstriction does not play a vital role in enhanced airway responsiveness to capsaicin or prostaglandin F-2 alpha. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 39]
机译：先前暴露于木烟中的气道导致豚鼠随后呼吸道吸入的气道反应性增加（Life Sci。63：1513，1998; 66：971,2000）。为了进一步表征这种气道反应性过高，我们调查并比较了在麻醉和人工通风的豚鼠中假空气暴露或木烟暴露之前和之后30分钟，气道对支气管收缩刺激的反应性。各种剂量的P物质（0.8-6.4杯/千克），辣椒素（0.2-3.2杯/千克），前列腺素F-2 alpha（30-3000杯/千克），组胺（1-8杯/千克）或乙酰胆碱以2分钟的间隔静脉内注射（5-20​​杯/ kg），以逐渐增加的剂量获得引起基线总肺阻力（ED200）增加200％所需的剂量。暴露于木烟中可显着降低P物质，辣椒素和前列腺素F-2α的ED200，而深空气暴露则不能。此外，木材烟雾暴露并没有显着改变组胺或乙酰胆碱的ED200。在烟雾接触前，用中性内肽酶（P物质的主要降解酶）抑制剂磷酰胺（2 mg / kg）进行预处理，并不会显着影响烟雾诱导的P物质ED200的降低。暴露并没有显着改变烟雾引起的辣椒素或前列腺素F-2α的ED200降低。这些结果表明，气道暴露于木烟中会导致气道对P物质，辣椒素和前列腺素F-2α产生过度反应，但对组胺或乙酰胆碱却没有。由于磷酰胺和木烟暴露的结合不会导致烟雾诱导的气道对物质Pit的高反应性的加性增强，提示对物质P降解酶的抑制可能有助于这种气道反应性的增加。此外，阴道介导的支气管收缩在增强对辣椒素或前列腺素F-2α的气道反应性中不发挥重要作用。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：39]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号