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首页> 外文期刊>Life sciences >Measurement of androgen and estrogen receptors in breast tissue from subjects with anabolic steroid-dependent gynecomastia.
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Measurement of androgen and estrogen receptors in breast tissue from subjects with anabolic steroid-dependent gynecomastia.

机译：合成代谢类固醇依赖型男性乳房发育症患者乳房组织中雄激素和雌激素受体的测量。

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摘要

In order to assess the relationship between anabolic steroid administration and gynecomastia, we studied the effects produced by administering nandrolone decanoate and a mixture of propionate, phenilpropionate, isocaproate and testosterone decanoate to bodybuilders during a six month period. The following significant changes occurred: a 53% reduction in serum testosterone; LH and FSH levels were suppressed to 77% and 87%, respectively, in comparison to control values; and although 45% of the subjects showed an increase in serum estradiol levels, no statistically significant differences were found compared with control estradiol levels. With regard to estradiol and androgen receptors, 85% of gynecomastia tissue contained estradiol or androgen receptors, while 40% contained both. The mean values of estradiol and androgen receptors in the cytosol were 65 +/- 10 and 52 +/- 5 fmol/mg protein, respectively. Nuclear androgen and estradiol receptor levels were 33 +/- 7 and 67.5 +/- 9 fmol/mg protein, respectively. The presence of hormone receptors in gynecomastia receptive cells provides support for the hypothesis that gynecomastia is steroid-dependent.
机译：为了评估合成代谢类固醇给药与男性乳房发育之间的关系，我们研究了在六个月的时间内向健美运动员服用癸酸诺龙和癸酸丙酸酯，苯丙酸酯，异辛酸和睾丸激素的混合物所产生的效果。发生了以下重大变化：血清睾丸激素降低53％;与对照值相比，LH和FSH水平分别被抑制到77％和87％。尽管45％的受试者血清雌二醇水平升高，但与对照组雌二醇水平相比，没有统计学上的显着差异。关于雌二醇和雄激素受体，女性乳房发育组织中有85％含有雌二醇或雄激素受体，而40％两者都含有。胞质溶胶中雌二醇和雄激素受体的平均值分别为65 +/- 10和52 +/- 5 fmol / mg蛋白。核雄激素和雌二醇受体水平分别为33 +/- 7和67.5 +/- 9 fmol / mg蛋白。男性乳房发育接受细胞中激素受体的存在为男性乳房发育是类固醇依赖的假说提供了支持。

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