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首页> 外文期刊>Life sciences >Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells.
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Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells.

机译：库普弗细胞介导大鼠肝脏中乙醇依赖性胆红素UDP-葡萄糖醛酸转移酶的诱导。

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摘要

Recently we have reported that bilirubin UDP-glucuronosyltransferase (UGT1A1) is induced in rat liver by chronic ethanol treatment. Several studies have shown that Kupffer cells play a central role in the mediation of various hepatic effects of chronic alcohol consumption. In the present work, the participation of Kupffer cells in the ethanol dependent induction of UGT1A1 was investigated. A group of rats was pretreated with gadolinium chloride, a known Kupffer-cell-depleting agent. We compared the effect of chronic ethanol ingestion on UGT1A1 expression in the liver of normal and gadolinium chloride treated rats. The effect of ethanol on bilirubin glucuronidation was completely prevented in Kupffer cell deficient rats. The western and northern blot analyses showed that the increase of both the protein and mRNA of UGT1A1 was prevented in these animals. These results suggest that Kupffer cells play a major role in the mediation of ethanol-stimulated induction of UGT1A1 in liver parenchymal cells.
机译：最近，我们报道了通过慢性乙醇治疗在大鼠肝脏中诱导胆红素UDP-葡萄糖醛酸转移酶（UGT1A1）。多项研究表明，枯否细胞在慢性饮酒的各种肝效应的介导中起着核心作用。在目前的工作中，研究了枯否细胞参与UGT1A1乙醇依赖性诱导的过程。一组大鼠用已知的枯否细胞枯竭剂氯化cell进行了预处理。我们比较了慢性乙醇摄入对正常和氯化chloride治疗的大鼠肝脏中UGT1A1表达的影响。在枯否细胞不足的大鼠中，乙醇对胆红素葡萄糖醛酸苷化的作用被完全阻止。 Western和Northern印迹分析表明，在这些动物中，UGT1A1的蛋白质和mRNA的增加均被阻止。这些结果表明，枯否细胞在肝实质细胞中在乙醇刺激的UGT1A1介导的介导中起主要作用。

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