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首页> 外文期刊>Life sciences >Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.
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Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.

机译：短效和长效多巴胺激动剂对单侧6-OHDA损伤大鼠致敏多巴胺能神经传递的影响。

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The effects of short and long-acting dopamine agonists on sensitized dopaminergic transmission in an animal model of Parkinson's disease were investigated. Rats with 6-hydroxydopamine (6-OHDA) lesions of the left nigrostriatal dopaminergic pathway were pre-exposed i.p. to 50 mg/kg methyl levodopa for 10 days. After a 7-day withdrawal period, these animals were treated with saline i.p., 0.05 mg/kg apomorphine s.c., or 0.5 mg/kg cabergoline i.p., once daily for 7 days. On the 8th day, rats in each treatment group received a challenge dose of 0.05 mg/kg apomorphine or saline s.c. The temporal changes in the number of rotations away from the 6-OHDA lesion side were evaluated after the challenge. The apomorphine challenge increased the number of rotations more markedly in the apomorphine pretreated rats than in the other pretreatment groups. In cabergoline pretreated rats, the number of rotations was significantly lower than that of saline-pretreated animals. Pretreatment with saline did not alter the apomorphine sensitivity of rotational behavior. These findings suggest that the repeated administration of long-acting dopamine agonists may reduce sensitized dopaminergic transmission in dopamine-depleted rats, whereas short-acting ones may further enhance sensitization of the transmission process.
机译：在帕金森氏病动物模型中，研究了短效和长效多巴胺激动剂对致敏多巴胺能传递的影响。腹膜内暴露有左黑质纹状体多巴胺能途径的6-羟基多巴胺（6-OHDA）损伤的大鼠。至50 mg / kg甲基左旋多巴10天。停药7天后，每天用生理盐水，0.05 mg / kg阿朴吗啡皮脂或0.5 mg / kg卡麦角林i.p.处理这些动物，每天一次，共7天。在第8天，每个治疗组中的大鼠接受0.05mg / kg阿扑吗啡或盐水皮下注射的激发剂量。攻击后评估远离6-OHDA病变侧的旋转数随时间的变化。与其他预处理组相比，在阿朴吗啡预处理的大鼠中，阿扑吗啡激发增加了转数。在卡麦角林预处理的大鼠中，转数明显低于生理盐水预处理的动物。用盐水预处理不会改变阿扑吗啡对旋转行为的敏感性。这些发现表明，反复服用长效多巴胺激动剂可能会降低多巴胺缺乏大鼠的致敏多巴胺能传递，而短效多巴胺激动剂可能会进一步增强传递过程的敏感性。

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