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首页> 外文期刊>Life sciences >Disruption of sensitization to methylphenidate by a single administration of MK-801.
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Disruption of sensitization to methylphenidate by a single administration of MK-801.

机译：一次服用MK-801会破坏对哌醋甲酯的敏化作用。

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Blockade of sensitization to methylphenidate by a single injection of MK-801 was investigated using a computerized activity monitoring system. Male Sprague-Dawley rats were housed in test cages and motor activity was recorded continuously for 16 days. After 2 days of baseline recording and a saline injection on day 3, the rats were randomly divided into four experimental groups. All received 2.5 mg/kg of methylphenidate (s.c.) once a day from days 4 to 9, then after five days of no treatment, they were re-challenged with 2.5 mg/kg of methylphenidate on day 15. One group received only methylphenidate, while the other three groups also received a single i.p. injection of MK-801 (0.30 mg/kg) either 24 h (day 3) or 1 h prior to the first of the six methylphenidate injections (day 4), or 1 h prior to the second methylphenidate injection (day 5). A single injection of MK-801 on day 4 (1 h prior to methylphenidate) blocked the development of sensitization to methylphenidate, since a sensitized response could not be elicited six days after cessation of repeated methylphenidate administration (day 15). However, sensitization to methylphenidate still occurred in the groups receiving MK-801 (0.30 mg/kg) on day 5, indicating that the mechanism by which a single injection of MK-801 disrupts sensitization to methylphenidate is sensitive to timing and is not a direct long-term effect. In conclusion, a single injection of MK-801 persistently blocks the development of sensitization to methylphenidate only if it is given with methylphenidate on the first day of the repetitive treatment phase.
机译：使用计算机化的活动监测系统研究了一次注射MK-801对哌醋甲酯致敏的阻滞作用。将雄性Sprague-Dawley大鼠关在测试笼中，并连续记录运动活动16天。在基线记录2天和第3天注射盐水后，将大鼠随机分为四个实验组。所有患者从第4天到第9天每天接受2.5 mg / kg哌醋甲酯（sc），然后在不治疗5天后，在第15天用2.5 mg / kg哌醋甲酯再次激发，一组仅接受哌醋甲酯，而其他三个组也获得了一个IP在六次哌醋甲酯注射后第24天（第3天）或1小时（第4天）或在第二次哌醋甲酯注射前1小时（第5天）注射MK-801（0.30 mg / kg）。在第4天（哌醋甲酯之前1小时）单次注射MK-801会阻止对哌醋甲酯的敏化，因为在停止重复哌醋甲酯给药后第6天（第15天）无法引起敏化反应。但是，在第5天接受MK-801（0.30 mg / kg）的组中仍然发生对哌醋甲酯的敏化，表明单次注射MK-801破坏对哌醋甲酯敏化的机制对时间敏感，不是直接的。长期效果。总之，单次注射MK-801仅在重复治疗阶段的第一天与哌醋甲酯联用时才会持久阻止对哌醋甲酯的敏化。

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