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alpha(1)-Adrenergic receptor subtypes: non-identical triplets with different dancing partners?

机译：alpha（1）-肾上腺素能受体亚型：具有不同舞蹈伴的三胞胎吗？

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摘要

alpha(1)-Adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their transmembrane domains but not in their amino or carboxyl termini. Recent advances in our understanding of these non-identical triplets single or multiple subtypes, new insights into subcellular localization and trafficking, identification of allosteric modulators, and increasing evidence for an important role in brain function. Although all three subtypes activate the same G(q/11) signaling pathway, they also appear to interact with different protein binding partners. Recent evidence suggests they may also form dimers, and may initiate independent signals through pathways yet to be clearly elucidated. Thus, this subfamily represents a common phenomenon of a group of similar but non-identical receptor subtypes activated by the same neurotransmitter, whose individual functional roles remain to be clearly established.
机译：α（1）-肾上腺素能受体是由肾上腺素和去甲肾上腺素激活以控制许多靶器官重要功能的G蛋白偶联受体的三个亚家族之一。三种人类亚型（alpha（1A），alpha（1B），alpha（1D））分别来自不同的基因，并且在其跨膜结构域中高度同源，但在其氨基或羧基末端却高度同源。我们对这些不相同的三胞胎单个或多个亚型的了解，对亚细胞定位和运输的新见解，变构调节剂的鉴定以及在脑功能中起重要作用的证据越来越多，这些方面的最新进展。尽管所有三个亚型都激活相同的G（q / 11）信号通路，但它们也似乎与不同的蛋白结合伴侣相互作用。最近的证据表明它们也可能形成二聚体，并可能通过尚不清楚的途径引发独立的信号。因此，该亚家族代表了由相同的神经递质激活的一组相似但不相同的受体亚型的普遍现象，其个别功能作用尚待明确。

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