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In vitro regulation of corticotropin-releasing hormone.

机译：促肾上腺皮质激素释放激素的体外调节。

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Studies involving regulation of corticotropin-releasing hormone (CRH) in vitro have been used to validate findings obtained in vivo and more importantly have been used as model systems to better understand signalling mechanisms responsible for the expression of the CRH gene and peptide. Many in vitro studies examining CRH have utilized hypothalamic tissue while a few have focused on the amygdala. Clonal cell lines have also been utilized as models of central nervous system CRH neurons. Stimuli that have been implicated in regulating hypothalamic CRH regulation in vitro include protein kinase A (PKA) and protein kinase C (PKC) activators, glucocorticoids, biogenic amines, cytokines and the gaseous neurotransmitters. Amygdalar CRH levels in vitro are affected by some of the same stimuli that regulate hypothalamic CRH; however there is evidence supporting differential regulation of CRH in these two brain regions by some of the same stimuli. Only a few studies in aggregate have investigated signal transduction mechanisms and these studies have focused on PKA- and glucocorticoid-mediated changes in CRH expression. Thus, much more investigative work in better understanding CRH regulation in vitro is needed.
机译：涉及体外调节促肾上腺皮质激素释放激素（CRH）的研究已用于验证在体内获得的发现，更重要的是已被用作模型系统以更好地理解负责CRH基因和肽表达的信号传导机制。许多检查CRH的体外研究已经利用了下丘脑组织，而一些研究集中在杏仁核上。克隆细胞系也已被用作中枢神经系统CRH神经元的模型。与体外下丘脑CRH调节有关的刺激包括蛋白激酶A（PKA）和蛋白激酶C（PKC）活化剂，糖皮质激素，生物胺，细胞因子和气态神经递质。体外杏仁核CRH水平受到一些调节下丘脑CRH的刺激的影响。然而，有证据支持某些相同刺激在这两个大脑区域对CRH的差异调节。总的来说，只有少数研究调查了信号转导机制，这些研究集中于PKA和糖皮质激素介导的CRH表达变化。因此，需要进行更多的研究工作以更好地了解体外CRH调节。

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