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首页> 外文期刊>Life sciences >Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals.
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Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals.

机译：通过饮食（n-6）多不饱和磷脂酰胆碱预防动物中环孢菌素A引起的肝内胆汁淤积。

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摘要

Previous findings showed that dietary (n-6) polyunsaturated phosphatidylcholines (vegetable lecithin) could efficiently prevent intrahepatic cholestasis induced by cyclosporine A in rats. Mechanistic studies showed that expressions in rat liver of Na(+), K(+)-ATPase, Ca(2+), Mg(2+)-ATPase and F-actin were both decreased by drug administration and both enhanced by (n-6) lecithin enriched diet. There is a possible direct effect of phosphatidylcholines, vectors of polyunsaturated fatty acids provided by the metabolism of the dietary lecithin, on the aforesaid hepatic parameters. Such modulations by drug and diet result in reversed modifications of membrane composition and fluidity. Final outcome is decreased and enhanced bile lipid secretion by cyclosporine and vegetable lecithin enriched diet respectively. Moreover, we advance the hypothesis of a bypass process including a separate and functional actin-independent way for the non micellar and phospholipid-dependent secretion of bile lipids. The relationships between the ATPases, the microfilament components such as F-actin and the different transporters still remain to be clarified. Furthermore, one can speculate on beneficial effects in humans of diets enriched in vegetable lecithins that might prevent cholestasis induced by cyclosporine A.
机译：先前的发现表明，饮食中（n-6）的多不饱和磷脂酰胆碱（植物卵磷脂）可以有效地预防环孢素A诱导的大鼠肝内胆汁淤积。机理研究表明，大鼠肝脏中Na（+），K（+）-ATPase，Ca（2 +），Mg（2 +）-ATPase和F-肌动蛋白的表达均因药物给药而降低，且均受（n -6）富含卵磷脂的饮食。磷脂酰胆碱（由饮食卵磷脂代谢提供的多不饱和脂肪酸的载体）可能对上述肝脏参数有直接影响。药物和饮食的这种调节导致膜组成和流动性的反向改变。分别通过富含环孢菌素和植物卵磷脂的饮食降低和增强胆汁脂质分泌的最终结果。此外，我们提出了绕过过程的假说，该过程包括胆汁脂质的非胶束和磷脂依赖性分泌的独立且功能独立的肌动蛋白方式。 ATPase，微丝成分（例如F-actin）与不同转运蛋白之间的关系仍有待阐明。此外，人们可以推测富含植物卵磷脂的饮食对人类的有益作用，这种饮食可以预防环孢素A引起的胆汁淤积。

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