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首页> 外文期刊>Life sciences >Inhibition of tumor growth in vitro by the extract of fagopyrum cymosum (fago-c).
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Inhibition of tumor growth in vitro by the extract of fagopyrum cymosum (fago-c).

机译：荞麦荞麦提取物（fago-c）在体外抑制肿瘤生长。

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Fagopyrum cymosum (Trev.) Meisn has long been used in China to treat various ailments of the lung, including lung tumors. This study investigated whether Fagopyrum cymosum extract (Fago-c) has effects on other organs. Human cancer cells derived from 10 different organs were employed, and their growths as affected by Fago-c were investigated. It was found that the growth of cancer cells from lung, liver, colon, leukocytes and bone is inhibited by Fago-c. However, cancer cells derived from prostate, cervix, ovary and brain are not sensitive to Fago-c, and the extract stimulates the growth of cancer cells from breast (MCF-7). Synergistic inhibition effect of Fago-c and daunomycin was observed in human lung cancer cells (H460). Cellular proteins from H460 cells treated with Fago-c were analyzed by 2D-gel electrophoresis. A protein (M.W./pI = 20K/5.9) was induced. The Fago-c extract was analyzed by High Performance Liquid Chromatography (HPLC). Four major and twenty minor components were identified. These studies indicate that the effect of Fago-c in inhibiting the growth of cell lines derived from certain organs.
机译：荞麦荞麦（Trev。cymosum，Trev。）在中国长期以来一直用于治疗各种肺部疾病，包括肺部肿瘤。这项研究调查了荞麦提取物（Fago-c）是否对其他器官有影响。使用了来自10个不同器官的人类癌细胞，并研究了其受Fago-c影响的生长情况。发现Fago-c抑制了来自肺，肝，结肠，白细胞和骨骼的癌细胞的生长。但是，源自前列腺，子宫颈，卵巢和脑的癌细胞对Fago-c不敏感，其提取物刺激了乳腺癌癌细胞（MCF-7）的生长。在人肺癌细胞（H460）中观察到了Fago-c和道诺霉素的协同抑制作用。通过2D凝胶电泳分析了用Fago-c处理的H460细胞的细胞蛋白。诱导了蛋白质（M.W./pI＝20K/5.9）。 Fago-c提取物通过高效液相色谱（HPLC）进行分析。确定了四个主要组成部分和二十个次要组成部分。这些研究表明，Fago-c抑制某些器官来源的细胞系生长的作用。

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