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首页> 外文期刊>Life sciences >Serum paraoxonase activity decreases in rheumatoid arthritis.
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Serum paraoxonase activity decreases in rheumatoid arthritis.

机译：类风湿关节炎的血清对氧磷酶活性降低。

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OBJECTIVE: To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA). DESIGN AND METHODS: We investigated the serum enzyme activity and concentration of PON1 and their relationship with serum lipids, high-density lipoprotein (HDL) parameters, and acute phase reactants of serum amyloid A (SAA) and C-reactive protein (CRP) in patients with RA. RESULTS: Serum paraoxonase (PON) activity was significantly decreased in RA patients (n = 64, 131 +/- 53 micro mol/min/L) compared with healthy subjects (n = 155, 164 +/- 59) despite the absence of any difference in serum lipid levels between the two groups. This decrease of serum PON activity in RA patients was found in every genotype (Q/Q, Q/R, R/R) of PON1 at 192 Q/R. There was a different distribution in PON1 Q/R genotypes between RA patients and healthy subjects, and RA patients exhibited less (44%) positive PON1-Q than did the healthy subjects (66%). In a further investigation of age- and gender-matched subgroups of RA (n = 25) and healthy subjects (n = 25), not only serum PON activity, but also lecithin-cholesterol acyltransferase (LCAT) was found to be significantly decreased in RA patients (125 +/- 61 micro mol/min/L, 63.2 +/- 17.2 nmol/ml/hr/37 degrees C) than in healthy subjects (169 +/- 67, 74.7 +/- 19.5), respectively. PON1 and LCAT as well as HDL constituent apolipoprotein (apo) AI and apo AII, were altered significantly in RA patients. CONCLUSIONS: Acute-phase HDL, which is remodeled structurally and functionally in RA, might be less anti-atherogenic due to the impairment of original HDL function. These alterations of HDL in RA patients may explain in part the reported increase in cardiovascular mortality in patients with RA.
机译：目的：评估类风湿关节炎（RA）中对氧磷酶1（PON1）和高密度脂蛋白（HDL）的变化。设计与方法：我们调查了血清中PON1的酶活性和浓度以及它们与血脂，高密度脂蛋白（HDL）参数以及血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）的急性期反应物之间的关系。 RA患者。结果：与健康受试者（n = 155、164 +/- 59）相比，RA患者的血清对氧磷酶（PON）活性显着降低（n = 64、131 +/- 53 micro mol / min / L），尽管缺乏两组之间血脂水平的任何差异。在192 Q / R的PON1的每个基因型（Q / Q，Q / R，R / R）中都发现了RA患者血清PON活性的这种降低。 RA患者和健康受试者之间PON1 Q / R基因型的分布不同，并且RA患者与健康受试者（66％）相比，PON1 -Q阳性的比例更少（44％）。在对年龄（RA）和性别匹配的RA（n = 25）和健康受试者（n = 25）的亚组进行的进一步调查中，不仅发现血清PON活性，而且卵磷脂-胆固醇酰基转移酶（LCAT）均显着降低。 RA患者（125 +/- 61 micro mol / min / L，63.2 +/- 17.2 nmol / ml / hr / 37摄氏度）比健康受试者（169 +/- 67，74.7 +/- 19.5）分别高。 RA患者的PON1和LCAT以及HDL组成的载脂蛋白（apo）AI和apo AII发生了显着变化。结论：急性期HDL在RA中在结构和功能上进行了重构，由于原始HDL功能的损害，其抗动脉粥样硬化性可能较弱。 RA患者HDL的这些改变可能部分解释了RA患者心血管死亡率的报道。

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