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首页> 外文期刊>Life sciences >Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.
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Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.

机译：间-氯苯基哌嗪的歧视性刺激作用是5-羟色胺受体在焦虑中作用的模型。

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Serotonin is known to play a role in anxiety. The roles of serotonin reuptake and 5-HT1A receptors have been well characterized, but the contribution of other serotonin receptor subtypes is not as clear. 1-(3-Chlorophenyl)-piperazine (mCPP), which binds non-selectively to a wide range of serotonin receptors, has often been used to produce anxiety in humans and in animal models. Because functional assays indicate that mCPP is significantly more potent at 5-HT2C receptors, it may serve as a tool to investigate the contribution of 5-HT2C receptors to anxiety. This paper reviews the results of behavioral tests using mCPP, including the drug discrimination assay, to model anxiety. Although the discriminative stimulus effects of mCPP do not seem to be a useful screen for general anxiolytics, they do seem to be useful for characterization of the contribution of 5-HT1B and 5-HT2C receptors to the mediation of anxiety-like behaviors.
机译：血清素在焦虑中起作用。 5-羟色胺再摄取和5-HT1A受体的作用已被很好地表征，但其他5-羟色胺受体亚型的贡献尚不清楚。 1-（3-氯苯基）-哌嗪（mCPP）与多种5-羟色胺受体非选择性结合，通常用于在人类和动物模型中产生焦虑。由于功能分析表明mCPP对5-HT2C受体的作用明显更强，因此它可以作为研究5-HT2C受体对焦虑的作用的工具。本文回顾了使用mCPP进行行为测试的结果，包括药物歧视试验，以模拟焦虑症。尽管mCPP的歧视性刺激作用似乎并不是一般抗焦虑药的有用筛选方法，但它们似乎确实有助于表征5-HT1B和5-HT2C受体对介导焦虑样行为的贡献。

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