• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >The potential role of cotinine in the cognitive and neuroprotective actions of nicotine.
【24h】

The potential role of cotinine in the cognitive and neuroprotective actions of nicotine.

机译：可替宁在尼古丁的认知和神经保护作用中的潜在作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cotinine is a primary metabolite of nicotine that has been suggested in many studies in animals and in humans to exert measurable effects on aspects of on-going behavior or on cognitive function. Much of the interest in cotinine derives from its long pharmacological half-life (15-19 hours) relative to nicotine (2-3 hours). Despite decades of study focusing on nicotine as the predominant behaviorally active component of tobacco, there continue to be aspects of the pharmacology of the drug that have yet to be explained. For example, nicotine can evoke a protracted behavioral response, i.e., in great excess of the presence of the drug in the plasma. Also, there is often a striking differential between the potency for nicotine-induced behavioral responses in humans and animals, and its potency as a cholinergic agonist, neurochemically. One possibility that may explain one or more of these properties of nicotine is the presence of a long-lived bioactive metabolite or breakdown product of nicotine such as cotinine. Preliminary data in support of this hypothesis are consistent with the ability of cotinine to improve performance accuracy on delayed matching task by macaque monkeys, and in reversing apomorphine-induced deficits in prepulse inhibition of acoustic startle in rats. The drug also was shown to be as potent as nicotine in the ability to act as a cytoprotective agent in cells that express a neuronal cholinergic phenotype. This new appreciation for the role of cotinine in nicotine's actions, and as a pharmacological agent in its own right, particularly in aspects of cognitive function and for neuroprotection, ultimately may be applied towards the treatment of Alzheimer's disease and related disorders, and for various psychiatric syndromes.
机译：可替宁是尼古丁的主要代谢产物，在动物和人类的许多研究中已提出可替宁对正在进行的行为或认知功能方面具有可测量的作用。对可替宁的大部分兴趣源于其相对于尼古丁（2-3小时）的长药理半衰期（15-19小时）。尽管数十年来的研究都集中于尼古丁作为烟草的主要行为活性成分，但该药物的药理学方面仍然有待解释。例如，尼古丁会引起长期的行为反应，即大大超过血浆中药物的存在。而且，在尼古丁引起的人和动物行为反应的效价与作为神经化学胆碱能激动剂的效价之间通常存在惊人的差异。可能解释尼古丁这些特性中的一种或多种的一种可能性是存在长寿命的生物活性代谢物或尼古丁的分解产物，例如可替宁。支持该假说的初步数据与可替宁提高猕猴在延迟匹配任务时的表现准确性的能力以及逆转阿扑吗啡引起的大鼠惊吓声脉冲抑制中的缺陷时的能力相符。在表达神经元胆碱能表型的细胞中，该药还具有与尼古丁一样强的细胞保护作用。对可替宁在尼古丁作用中的作用以及作为其本身的药理作用，特别是在认知功能和神经保护方面的作用的这种新认识，最终可用于治疗阿尔茨海默氏病和相关疾病以及各种精神病学综合症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号