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首页> 外文期刊>Life sciences >Agmatine attenuates neuropathic pain in rats: possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum.
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Agmatine attenuates neuropathic pain in rats: possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum.

机译：胍丁胺减轻大鼠的神经性疼痛：脑干和小脑中一氧化氮和去甲肾上腺素能活动的可能介导。

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摘要

Effect of agmatine (10-400 mg/kg) on neuropathic pain in a rat model produced by loose ligatures around the common sciatic nerve was studied. The involvement of possible alterations in nitric oxide (NO) levels [measured as its stable metabolites nitrate + nitrite] and in noradrenergic activity [measured as norepinephrine and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) levels] in this effect was also investigated biochemically in the brainstem and cerebellum. Agmatine increased the neuropathic pain threshold at 300 and 400 mg/kg. There was almost a twofold increase in nitrate + nitrite levels in the brainstem and cerebellum of the rats with neuropathic pain and agmatine decreased the high nitrate + nitrite levels only in the brainstem at 300 mg/kg and both in the brainstem and cerebellum at 400 mg/kg. Ligation of sciatic nerve resulted in almost twofold increase in norepinephrine and MHPG levels only in the brainstem of the rats. Agmatine decreased MHPG levels at 300 and 400 mg/kg, however it decreased norepinephrine levels only at the higher dose. These findings indicate that agmatine decreases neuropathic pain, an effect which may involve the reduction of NO levels and noradrenergic activity in the brain.
机译：研究了胍丁胺（10-400 mg / kg）对大鼠坐骨神经周围松散结扎产生的神经性疼痛的影响。还研究了一氧化氮（NO）水平[以其稳定的代谢产物硝酸盐+亚硝酸盐测量]和去甲肾上腺素能活性[以去甲肾上腺素和3-甲氧基-4-羟基苯基乙二醇（MHPG）水平测量]的可能变化。生化在脑干和小脑。胍丁胺将神经性疼痛阈值提高到300和400 mg / kg。神经性疼痛大鼠的脑干和小脑中硝酸盐+亚硝酸盐水平几乎增加了两倍，胍丁胺仅以300 mg / kg的量在脑干中降低了高硝酸盐+亚硝酸盐水平，在400 mg / kg的脑干和小脑中均降低了/公斤。坐骨神经结扎仅在大鼠脑干中导致去甲肾上腺素和MHPG水平增加几乎两倍。胍丁胺在300和400 mg / kg时可降低MHPG水平，但仅在较高剂量时可降低去甲肾上腺素水平。这些发现表明，胍丁胺减轻了神经性疼痛，这种作用可能涉及降低脑中NO水平和去甲肾上腺素能活动。

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