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Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma

机译：蛋白激酶p-JNK与肝细胞癌AP-1及其相关的Jun家族蛋白的激活有关

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摘要

To study the role of c-Jun N-terminal kinase (JNK) and its relation to transcription factor AP-1 and Jun family proteins in hepatocellular carcinoma (HCC) with or without hepatitis B virus (HBV) infection. Immunohistochemical and in situ hybridization techniques were performed for studying phosphorylated JNK (p-JNK), c-Jun, JunB, JunD and AP-1 in 40 cases of human HCC and corresponding nontumoral tissues. Positive staining of nucleus for p-JNK, c-Jun, JunD and AP-1 was presented in 28 (70%), 29 (72.5%), 32 (80%) and 25 (62.5%) in cancer cells respectively, while 0%, 28%, 17.5% and 10% in adjacent non-tumor tissues. The expression levels of p-JNK, c-Jun, JunD and AP-1 were significantly and positively correlated with each other and with HBsAg positive rate (P < 0.05). JunB was negative staining in both cancer cells and non-tumor tissues of all cases. JNK phosphorylation may correlate with AP-1 activation and the expression of c-Jun and JunD in HCC. JNK/c-Jun/ JunD/AP-1 signaling pathway may play an important role in the pathogenesis of HBV-associated HCC. JunB may not be involved in the process. (c) 2005 Elsevier Inc. All rights reserved.
机译：研究c-Jun N-末端激酶（JNK）的作用及其与转录因子AP-1和Jun家族蛋白在有或没有乙型肝炎病毒（HBV）感染的肝细胞癌（HCC）中的关系。进行了免疫组织化学和原位杂交技术，以研究40例人HCC和相应非肿瘤组织中的磷酸化JNK（p-JNK），c-Jun，JunB，JunD和AP-1。在癌细胞中，p-JNK，c-Jun，JunD和AP-1的细胞核呈阳性，分别为28（70％），29（72.5％），32（80％）和25（62.5％）。在相邻的非肿瘤组织中分别为0％，28％，17.5％和10％。 p-JNK，c-Jun，JunD和AP-1的表达水平相互之间以及与HBsAg阳性率均呈显着正相关（P <0.05）。在所有病例的癌细胞和非肿瘤组织中，JunB均为阴性染色。 JNK磷酸化可能与肝癌中AP-1的活化以及c-Jun和JunD的表达有关。 JNK / c-Jun / JunD / AP-1信号通路可能在HBV相关HCC的发病机理中起重要作用。 JunB可能不参与该过程。 （c）2005 Elsevier Inc.保留所有权利。

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