• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats.
【24h】

Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats.

机译：榕榕提取物对Wistar大鼠化学诱导的肾脏致癌作用和氧化损伤反应的化学调节作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ferric nitrilotriacetate (Fe-NTA) is a well-known renal carcinogen. In this communication, we show the chemopreventive effect of Ficus racemosa extract against Fe-NTA-induced renal oxidative stress, hyperproliferative response and renal carcinogenesis in rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H(2)O(2)) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [(3)H] incorporation into renal DNA. It also enhances DEN (N-diethylnitrosamine) initiated renal carcinogenesis by increasing the percentage incidence of tumors. Treatment of rats orally with F. racemosa extract (200 and 400 mg/kg body weight) resulted in significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H(2)O(2) generation, blood urea nitrogen, serum creatinine, renal ODC activity, DNA synthesis (P<0.001) and incidence of tumors. Renal glutathione content (P<0.01), glutathione metabolizing enzymes (P<0.001) and antioxidant enzymes were also recovered to significant level (P<0.001). Thus, our data suggests that F. racemosa extract is a potent chemopreventive agent and suppresses Fe-NTA-induced renal carcinogenesis and oxidative damage response in Wistar rats.
机译：次氮基三乙酸铁（Fe-NTA）是众所周知的肾致癌物。在本通讯中，我们显示了榕总督子提取物对Fe-NTA诱导的大鼠肾脏氧化应激，过度增殖反应和肾脏癌变的化学预防作用。 Fe-NTA（9 mg Fe / kg体重，腹膜内）增强肾脂质过氧化，黄嘌呤氧化酶，γ-谷氨酰转肽酶和过氧化氢（H（2）O（2））生成，同时减少了谷胱甘肽含量，抗氧化剂即，谷胱甘肽过氧化物酶，谷胱甘肽还原酶，过氧化氢酶，6-磷酸葡萄糖脱氢酶和II期代谢酶，例如谷胱甘肽S-转移酶和醌还原酶。它还可以增强血液尿素氮，血清肌酐，鸟氨酸脱羧酶（ODC）活性和将胸苷[（3）H]掺入肾DNA中。它还通过增加肿瘤的发生率来增强DEN（N-二乙基亚硝胺）引发的肾脏癌变。用消旋沙门氏菌提取物（分别为200和400 mg / kg体重）对大鼠进行口服治疗会导致γ-谷氨酰转肽酶，脂质过氧化，黄嘌呤氧化酶，H（2）O（2）生成，血尿素氮，血清显着降低肌酐，肾脏ODC活性，DNA合成（P <0.001）和肿瘤发生率。肾谷胱甘肽含量（P <0.01），谷胱甘肽代谢酶（P <0.001）和抗氧化酶也被恢复到显着水平（P <0.001）。因此，我们的数据表明，总状果提取物是一种有效的化学预防剂，可抑制Wistar大鼠中Fe-NTA诱导的肾脏癌变和氧化损伤反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号