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首页> 外文期刊>Life sciences >Effect of prenatal or perinatal nicotine exposure on neonatal thyroid status and offspring growth in rats.
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Effect of prenatal or perinatal nicotine exposure on neonatal thyroid status and offspring growth in rats.

机译：产前或围产期尼古丁暴露对大鼠甲状腺状态和后代生长的影响。

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Smoking during pregnancy causes intrauterine growth retardation and low birth weight of the offspring. However, it is unclear whether nicotine, rather than other compounds from a cigarette, would mediate long-term growth retardation. There is a body of evidence suggesting that optimal thyroid status is important for the normal development of the fetus. Therefore, these studies examined whether developmental nicotine exposure would interfere with the growth of the offspring and alter the thyroid status of neonates. Pregnant Sprague-Dawley rats were given 0, 15 or 25 mg nicotine pellets throughout pregnancy. Some offspring continued to receive 1 or 2 mg/kg/day nicotine during early postnatal period. The remaining offspring received no further treatment after birth. The body weight of all offspring was monitored until adulthood. Additionally, the neonatal thyroid status from all treatment groups was assessed from the serum of 10-day-old pups. Regardless of the timing of nicotine exposure, the nicotine treatment significantly increased the body weight in female offspring starting on postnatal day (PD) 35 and such an increase persisted into adulthood (PD 91). However, this nicotine exposure paradigm led to a transient increase in male offspring body weight on PD 35. Furthermore, current nicotine exposure regimens did not alter the total T4 level, T3 uptake and the calculated Free T4 index. The present findings are in agreement with some clinical studies reporting a higher body weight among children born to mothers who smoked during pregnancy. Furthermore, the data on thyroid status suggest that cigarette smoking-induced alterations in thyroid status might be mediated through compounds in cigarettes other than nicotine.
机译：怀孕期间吸烟会导致宫内发育迟缓，并降低后代的出生体重。但是，尚不清楚尼古丁而不是香烟中的其他化合物会介导长期生长迟缓。有大量证据表明，最佳甲状腺状态对胎儿的正常发育很重要。因此，这些研究检查了发育性尼古丁暴露是否会干扰后代的生长并改变新生儿的甲状腺状况。在整个怀孕期间，给怀孕的Sprague-Dawley大鼠服用0、15或25 mg尼古丁颗粒。在产后早期，一些后代继续接受1或2 mg / kg /天的尼古丁。其余的后代在出生后未接受进一步治疗。监测所有后代的体重直至成年。另外，从10日龄幼犬的血清中评估所有治疗组的新生儿甲状腺状态。无论何时接触尼古丁，尼古丁治疗都会从出生后第35天开始显着增加雌性后代的体重，并且这种增加一直持续到成年后（PD 91）。但是，这种尼古丁暴露范例导致PD 35上雄性后代体重暂时增加。此外，目前的尼古丁暴露方案并未改变总T4水平，T3摄取和计算的游离T4指数。目前的发现与一些临床研究相吻合，一些临床研究报道了在怀孕期间吸烟的母亲所生的孩子中体重较高。此外，有关甲状腺状态的数据表明，吸烟引起的甲状腺状态改变可能是通过香烟中除尼古丁以外的化合物介导的。

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