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首页> 外文期刊>Life sciences >Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression.
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Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression.

机译：Chaihu-Shugan-San提取物及其成分在抑郁症大鼠模型中的抗抑郁作用。

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摘要

Herbal preparations may be effective alternatives in the treatment of depression, which remains difficult to manage. Chaihu-Shugan-San (CSS), an oriental traditional medicine, has been used as a remedy for Hwa-Byung, a Korean culture-bound syndrome resembling depression. We examined whether aqueous extracts of CSS and its constituent herbs exert antidepressant-like effects in two experimental animal models: the forced swimming test (FST) and the chronic mild stress (CMS) model. The herbal extracts were administered orally for 7 days in the FST and for 21 days during the CMS model; imipramine at 20 mg/kg/day was injected intraperitoneally as a positive control. CSS, Radix Bupleuri (one of the most important constituent plants in CSS), and imipramine had significant anti-immobility effects in the FST and reversed the CMS-induced reduction in sucrose consumption. Rhizoma Cyperi, another constituent of CSS, had antidepressant activity in the FST, while it failed in the CMS model. In conclusion, our resultssuggest that CSS and its constituent herbs exert antidepressant-like effects comparable to those of imipramine in experimental animal models.
机译：草药制剂可能是治疗抑郁症的有效替代品，抑郁症仍然难以治疗。 Chaihu-Shugan-San（CSS）是一种东方传统药物，已被用作治疗与韩国文化相似的抑郁症综合征Hwa-Byung的药物。我们在两个实验动物模型（强制游泳试验（FST）和慢性轻度应激反应（CMS）模型）中检查了CSS的水提取物及其组成草药是否具有抗抑郁样作用。在FST中将草药提取物口服7天，在CMS模型中口服21天;腹膜内注射20 mg / kg /天的丙咪嗪作为阳性对照。 CSS，Radix Bupleuri（CSS中最重要的组成植物之一）和丙咪嗪在FST中具有显着的抗固定作用，并逆转了CMS诱导的蔗糖消耗量减少。 CSS的另一种成分，香根草在FST中具有抗抑郁活性，而在CMS模型中则具有抗抑郁活性。总之，我们的结果表明，在实验动物模型中，CSS及其组成草药具有的抗抑郁作用与丙咪嗪相当。

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