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Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells.

机译:来自三七的人参皂苷-Rd增强星形胶质细胞从神经干细胞的分化。

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摘要

Neural stem cells cultured as neurospheres were used to assess the effects of P. notoginseng on the production of neurons and glia. The crude saponins (PNS) and ginsenoside-Rd promote the differentiation of neurospheres into astrocytes. Ginsenoside-Rd increases the production of astrocytes in a dose-dependent manner. On the other hand, both PNS and ginsenoside-Rd induce a weak but significant effect by decreasing the number of neurons. The other ginsenosides do not induce any differentiation on both neurons and astrocytes.
机译:将神经干细胞培养成神经球用于评估三七对神经元和神经胶质细胞产生的影响。粗皂苷(PNS)和人参皂苷Rd促进神经球向星形胶质细胞的分化。人参皂苷-Rd以剂量依赖性方式增加星形胶质细胞的产生。另一方面,PNS和人参皂苷-Rd都通过减少神经元数量而诱导了微弱但显着的作用。其他人参皂甙在神经元和星形胶质细胞上均未诱导任何分化。

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