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首页> 外文期刊>Life sciences >Anti-diabetic activity of the semi-purified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin-induced diabetic rats
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Anti-diabetic activity of the semi-purified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin-induced diabetic rats

机译：高脂饮食喂养的链脲佐菌素诱导的糖尿病大鼠中半叶苍黄的半纯化级分的抗糖尿病活性

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摘要

The present study was designed to investigate the hypoglycemic and hypolipidemic activities of the semipurified fractions of an ethanolic leaf extract of Averrhoa bilimbi (ABe) in high fat diet (HFD)-streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats aged 10 weeks (200-250 g) were fed with a high fat diet obtained from Glen Forrest stock feeders (Western Australia) for 2 weeks prior to intraperitoneal injection with streptozotocin (STZ, 50 mg/kg). The leaves of A.bilimbi were exhaustively extracted with 80% ethanol, concentrated at 40 degrees C using a rotavapor and partitioned successively with butanol, ethylacetate and hexane to get aqueous (AF), butanol (BuF), ethylacetate (EF), and hexane fractions (HF). The fractions were freezedried to obtain powders of each. To investigate the effect of long term administration of the hypoglycemic fractions, diabetic animals were treated with vehicle (distilled water), AF (125 mg/kg), or BuF (125 mg/kg), twice a day for 14 days. The long term administration of AF and BuF at a dose of 125 mg/kg significantly (P < 0.05) lowered blood glucose and triglyceride concentrations when compared to the vehicle. The hepatic glycogen content was significantly higher (P < 0.05) in AF-treated rats when compared to diabetic control, however no chan-e was found in the BuF-treated rats. Moreover, AF as well as BuF did not cause any significant change in the total cholesterol and HDL-cholesterol. There was also no difference in liver thiobarbituric acid reactive substances (TBARS) and cytochrome P-450 values between AF, BuF and vehicle treated control rats. In conclusion, the results indicate that AF is more potent than BuF in the amelioration of hyperglycemia and hyperlipidemia in HFD fed-STZ diabetic rats. Hence, AF is a potential source for the isolation of active principle (s) for oral anti-diabetic therapy. (c) 2005 Elsevier Inc. All rights reserved.
机译：本研究旨在研究高脂饮食（HFD）-链脲佐菌素（STZ）诱导的糖尿病大鼠半叶苍白（ABe）乙醇叶提取物的半纯化级分的降血糖和降血脂活性。在腹膜内注射链脲佐菌素（STZ，50 mg / kg）之前，对10周龄（200-250 g）的雄性Sprague-Dawley大鼠（200-250 g）饲喂从Glen Forrest饲养器（西澳大利亚州）获得的高脂饮食2周。用80％乙醇彻底提取A.bilimbi的叶子，使用旋转蒸发仪在40°C下浓缩，然后依次用丁醇，乙酸乙酯和己烷分配，得到水（AF），丁醇（BuF），乙酸乙酯（EF）和己烷分数（HF）。将级分冷冻干燥以获得每种的粉末。为了研究长期给予降血糖成分的作用，每天两次用赋形剂（蒸馏水），AF（125 mg / kg）或BuF（125 mg / kg）治疗糖尿病动物，共14天。与赋形剂相比，以125 mg / kg的剂量长期给予AF和BuF可以显着降低（P <0.05）血糖和甘油三酸酯浓度。与糖尿病对照组相比，AF治疗组大鼠肝糖原含量明显更高（P <0.05），但是在BuF治疗组大鼠中未发现chan-e。此外，AF和BuF不会引起总胆固醇和HDL-胆固醇的任何显着变化。 AF，BuF和溶媒处理的对照组大鼠之间的肝硫代巴比妥酸反应性物质（TBARS）和细胞色素P-450值也没有差异。总之，结果表明，在HFD喂养的STZ糖尿病大鼠中，AF比BuF更有效地改善高血糖和高血脂。因此，AF是隔离口服抗糖尿病治疗有效成分的潜在来源。 （c）2005 Elsevier Inc.保留所有权利。

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