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首页> 外文期刊>Life sciences >Exercise training exacerbates tourniquet ischemia-induced decreases in GLUT4 expression and muscle atrophy in rats
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Exercise training exacerbates tourniquet ischemia-induced decreases in GLUT4 expression and muscle atrophy in rats

机译：运动训练加剧了止血带缺血引起的大鼠GLUT4表达下降和肌肉萎缩

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摘要

The current study determined the interactive effects of ischemia and exercise training on glycogen storage and GLUT4 expression in skeletal muscle. For the first experiment, an acute 1-h tourniquet ischemia was applied to one hindlimb of both the 1-week exercise-trained and untrained rats. The contralateral hindlimb served as control. For the second experiment, 1-h ischernia was applied daily for 1 week to both trained (5 h postexercise) and untrained rats. GLUT4 mRNA was not affected by acute ischernia, but exercise training lowered GLUT4 mRNA in the acute ischemic muscle. GLUT4 protein levels were elevated by exercise training, but not in the acute ischemic muscle. Exercise training elevated muscle glycogen above untrained levels, but this increase was reversed by chronic ischemia. GLUT4 mRNA and protein levels were dramatically reduced by chronic ischemia, regardless of whether the animals were exercise-trained or not. Chronic ischemia significantly reduced plantaris muscle mass, with a greater decrease found in the exercise-trained rats. In conclusion, the exercise training effect on muscle GLUT4 protein expression was prevented by acute ischemia. Furthermore, chronic ischemia-induced muscle atrophy was exacerbated by exercise training. This result implicates that exercise training could be detrimental to skeletal muscle with severely impaired microcirculation. (c) 2005 Elsevier Inc. All rights reserved.
机译：当前的研究确定了缺血和运动训练对骨骼肌糖原存储和GLUT4表达的相互作用。对于第一个实验，将急性1小时止血带缺血应用于接受1周运动训练和未经训练的大鼠中的一只后肢。对侧后肢作为对照。对于第二个实验，每天对训练过的大鼠（运动后5小时）和未训练的大鼠每天应用1小时的缺氧缺血1小时。 GLUT4 mRNA不受急性缺血的影响，但是运动训练降低了急性缺血肌肉中的GLUT4 mRNA。 GLUT4蛋白水平通过运动训练而升高，但在急性缺血性肌肉中并未升高。运动训练使肌肉糖原升高至未训练水平以上，但这种增加被慢性缺血逆转。无论动物是否经过运动训练，慢性缺血都会显着降低GLUT4 mRNA和蛋白水平。慢性缺血会显着降低足底肌质量，在运动训练的大鼠中会更大程度地降低。总之，急性缺血可预防运动训练对肌肉GLUT4蛋白表达的影响。此外，运动训练加剧了慢性缺血引起的肌肉萎缩。该结果暗示运动训练可能对骨骼肌有害，而微循环严重受损。 （c）2005 Elsevier Inc.保留所有权利。

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