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Decreased alpha(2)-adrenergic receptor in the brain stem and pancreatic islets during pancreatic regeneration in weanling rats

机译：断奶大鼠胰腺再生过程中脑干和胰岛中α（2）-肾上腺素受体的减少

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Sympathetic stimulation inhibits insulin secretion. alpha(2)-Adrenergic receptor is known to have a regulatory role in the sympathetic function. We investigated the changes in the alpha(2)-adrenergic receptors in the brain stem and pancreatic islets using [H-3]Yohimbine during pancreatic regeneration in weanling rats. Brain stem and pancreatic islets of experimental rats showed a significant decrease (p < 0.001) in norepinephrine (NE) content at 72 It after partial pancreatectomy. The epinephrine (EPI) content showed a significant decrease (p < 0.001) in pancreatic islets while it was not detected in brain stem at 72 It after partial pancreatectomy. Scatchard analysis of [H-3]Yohimbine showed a significant decrease (P < 0.05) in B-a, and K-d at 72 h after partial pancreatectomy in the brain stem. In the pancreatic islets, Scatchard analysis of [H-3]Yohimbine showed a significant decrease (p < 0.001) in B-max and K-d (p < 0.05) at 72 h after partial pancreatectomy. The binding parameters reversed to near sham by 7 days after pancreatectomy both in brain stem and pancreatic islets. This shows that pancreatic insulin secretion is influenced by central nervous system inputs from the brain stem. In vitro studies with yohimbine showed that the alpha(2)-adrenergic receptors are inhibitory to islet DNA synthesis and insulin secretion. Thus our results suggest that decreased alpha(2)-adrenergic receptors during pancreatic regeneration functionally regulate insulin secretion and pancreatic p-cell proliferation in weanling rats. (c) 2006 Elsevier Inc. All rights reserved.
机译：交感神经刺激抑制胰岛素分泌。已知α（2）-肾上腺素受体在交感神经功能中具有调节作用。我们调查了断奶大鼠胰腺再生过程中使用[H-3]育亨宾在脑干和胰岛中的α（2）-肾上腺素能受体的变化。实验大鼠的脑干和胰岛在部分胰腺切除术后72 It时去甲肾上腺素（NE）含量显着降低（p <0.001）。胰腺部分切除后，肾小岛中肾上腺素（EPI）含量显着降低（p <0.001），而脑干中未检测到。 [H-3]育亨宾的Scatchard分析显示，在部分脑干切除后72 h，B-a和K-d明显降低（P <0.05）。在胰岛中，[H-3]育亨宾的Scatchard分析显示，部分胰切除术后72小时，B-max和K-d显着降低（p <0.001）（p <0.05）。胰腺切除术后7天，脑干和胰岛的结合参数均恢复到接近假手术的水平。这表明胰腺胰岛素的分泌受脑干中枢神经系统输入的影响。育亨宾的体外研究表明，α（2）-肾上腺素受体抑制胰岛DNA合成和胰岛素分泌。因此，我们的结果表明，在胰腺再生过程中减少的alpha（2）-肾上腺素能受体功能性调节断奶大鼠的胰岛素分泌和胰腺p细胞增殖。 （c）2006 Elsevier Inc.保留所有权利。

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