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首页> 外文期刊>Life sciences >The effect of creatine supplementation on mass and performance of rat skeletal muscle.
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The effect of creatine supplementation on mass and performance of rat skeletal muscle.

机译：补充肌酸对大鼠骨骼肌质量和性能的影响。

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摘要

This study investigated the effect of dietary creatine supplementation on hypertrophy and performance of rat skeletal muscle. Male Sprague-Dawley rats underwent either tibialis anterior ablation or partial ablation of the plantaris/gastrocnemius to induce compensatory hypertrophy of the extensor digitorum longus (EDL) or soleus respectively, or sham surgery. Creatine (300 mg/kg) was administered to one half of each group for 5 weeks, after which force production was measured. With the leg fixed at the knee and ankle, the distal tendon of the EDL or soleus was attached to a force transducer and the muscle was electrically stimulated via the sciatic nerve. Synergist ablation resulted in a significant increase in EDL mass and in soleus mass relative to control muscles. However, no effect of creatine supplementation on muscle mass or performance was found between control and either group of creatine-treated rats. Despite an apparent increase in muscle creatine content, creatine supplementation did not augment muscle hypertrophy or force production in rat EDL or soleus muscle, providing evidence that the potential benefits of creatine supplementation are not due to a direct effect on muscle but rather to an enhanced ability to train.
机译：这项研究调查了膳食肌酸补充对大鼠骨骼肌肥大和性能的影响。对雄性Sprague-Dawley大鼠进行胫骨前消融或plant肌/腓肠肌部分消融，分别诱发长指伸肌（EDL）或比目鱼肌的代偿性肥大，或假手术。将肌酸（300 mg / kg）给予各组的一半，持续5周，然后测量力的产生。将腿固定在膝盖和脚踝处，将EDL或比目鱼的远侧肌腱连接至力传感器，并通过坐骨神经对肌肉进行电刺激。协同消融术导致EDL质量和比目鱼质量相对于对照肌肉显着增加。但是，在对照组和任一组经肌酸治疗的大鼠之间，均未发现补充肌酸对肌肉质量或性能的影响。尽管肌肉肌酸含量明显增加，但是补充肌酸并没有增加大鼠EDL或比目鱼肌中的肌肉肥大或力量，这表明补充肌酸的潜在益处不是由于对肌肉的直接影响，而是由于增强的能力培训。

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