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首页> 外文期刊>Life sciences >Prevention of ischemia-induced hippocampal neuronal damage by 2-deoxy-D-glucose in gerbils.
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Prevention of ischemia-induced hippocampal neuronal damage by 2-deoxy-D-glucose in gerbils.

机译：沙土鼠中的2-脱氧-D-葡萄糖预防缺血诱导的海马神经元损伤。

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It has been reported that delayed neuronal death (DND) in the hippocampus following transient forebrain ischemia is associated with internucleosomal DNA fragmentation, indicating apoptosis. This suggests that the process of DND is energy dependent. Transient severe forebrain ischemia was induced in Mongolian gerbils by bilateral occlusion of the common carotid arteries. Post-ischemic administration of 2-deoxy-D-glucose (2-DG), a glucose antimetabolite, markedly reduced the occurrence of ischemia-induced DNA fragmentation and DND in the hippocampus. These results suggest that the reduction of energy dependent metabolism after ischemia may be an attractive therapeutic strategy for preserving hippocampal neurons vulnerable to ischemia.
机译：据报道，短暂性前脑缺血后海马延迟神经元死亡（DND）与核糖体间DNA片段化有关，表明细胞凋亡。这表明DND的过程取决于能量。蒙古沙鼠因双侧颈总动脉闭塞而导致短暂性前脑缺血。缺血后给药的葡萄糖抗代谢物2-脱氧-D-葡萄糖（2-DG）明显减少了缺血诱导的海马DNA片段和DND的发生。这些结果表明，缺血后能量依赖性代谢的减少可能是保留易受缺血影响的海马神经元的有吸引力的治疗策略。

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