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Immunotherapy for experimental rat autoimmune thyroiditis using a novel immunosuppressant, FTY720

机译：使用新型免疫抑制剂FTY720对实验性大鼠自身免疫性甲状腺炎进行免疫治疗

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摘要

While autoimmune disease needs to be continuously treated via long term, administration of immunosuppressants conventional immunotherapy using drugs such as cyclosporin and tacrolimus may cause adverse effects. Recently, a novel agent, FTY720, which was structurally modified from a natural product, has been shown to have a moderate and different immunosuppressive effect from conventional drugs. In this study, we examined the effect of FTY720 on experimental autoimmune thyroiditis (EAT), which was induced in rats by neonatal thymectomy, followed by subsequent sublethal irradiation. Thyroid stimulating hormone (TSH) was measured before and at the end of drug therapy. Histological and hematological examinations were performed using the samples from sacrificed animals. High TSH levels in the animals returned to the normal range following treatment with FTY720. The severity of the thyroiditis was lower in the FTY720 group than in the control group. FTY720 markedly decreased the number of circulatory lymphocytes, and no infections episodes were observed under this treatment. Thus, FTY720 treatment might be preferred for continuous immunotherapy for autoimmune disease without adverse effects.
机译：虽然自身免疫性疾病需要长期持续治疗，但使用环孢菌素和他克莫司等药物进行免疫抑制剂常规免疫治疗可能会产生不良反应。近来，已显示出从天然产物进行结构修饰的新型药物FTY720与常规药物相比具有中等和不同的免疫抑制作用。在这项研究中，我们检查了FTY720对实验性自身免疫性甲状腺炎（EAT）的影响，该疾病由新生的胸腺切除术后继之以亚致死剂量照射在大鼠中诱发。在药物治疗之前和结束时测量甲状腺刺激激素（TSH）。使用处死动物的样品进行组织学和血液学检查。用FTY720处理后，动物体内的高TSH水平恢复到正常范围。 FTY720组甲状腺炎的严重程度低于对照组。 FTY720明显减少了循环淋巴细胞的数量，在这种治疗下未观察到感染发作。因此，对于自身免疫性疾病的连续免疫疗法，如果没有副作用，FTY720治疗可能更可取。

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