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首页> 外文期刊>Life sciences >The role of the sodium-calcium exchanger for calcium extrusion in coronary arteries.
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The role of the sodium-calcium exchanger for calcium extrusion in coronary arteries.

机译：钠钙交换剂在冠状动脉钙挤出中的作用。

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摘要

Calcium ionophores, such as the A23187, cause endothelium-dependent relaxation of arterial strips with intact endothelium, whereas the effect of the ionophore should result from the combination of a relaxation caused by the endothelium-dependent factors and of a contraction of the smooth muscles. In addition, the application of a calcium ionophore to a strip of pig coronary arteries without endothelium does not change cytosolic free calcium concentration and force developed by the smooth muscle cells. To explain these paradoxes, the hypothesis that active calcium extrusion would match the entry of extracellular calcium caused by the ionophore was tested. We see that the sodium-calcium exchanger extrudes calcium that enters the smooth muscle cells in the absence of the ionophore. This exchanger is efficient enough to expel the increased influx of calcium created by the additional calcium carriers formed by the ionophore. This explains the inefficiency of calcium ionophores to increase cytosolic free calcium of smooth muscle cells and consequently, the fact that the ionophore does not cause a contraction of a strip without endothelium. This makes evident that a calcium ionophore fully relaxes, in an endothelium-dependent manner. an intact strip of porcine coronary artery.
机译：钙离子载体，例如A23187，会导致完整血管内皮依赖性内皮条的舒张，而离子载体的作用应归因于内皮依赖性因子引起的舒张和平滑肌收缩的结合。另外，将钙离子载体应用于没有内皮的猪冠状动脉条带不会改变胞浆游离钙的浓度和平滑肌细胞产生的力。为了解释这些悖论，测试了活性钙挤出与离子载体引起的细胞外钙进入相匹配的假说。我们看到钠钙交换剂挤出了钙，而钙在没有离子载体的情况下进入了平滑肌细胞。该交换剂足够有效地排出由离子载体形成的额外钙载体产生的增加的钙流入。这解释了钙离子载体增加平滑肌细胞的胞质游离钙的效率低下，因此，离子载体不会引起没有内皮的条带收缩这一事实。这表明钙离子载体以内皮依赖性方式完全松弛。完整的猪冠状动脉条。

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