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Vitamin E, membrane fluidity, and blood pressure in hypertensive and normotensive rats

机译：高血压和正常血压大鼠的维生素E，膜流动性和血压

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Vitamin E treatment was found to lower blood pressure, and increase membrane fluidity in rats. The objectives of this study were to investigate the effects of the antioxidant, vitamin E, on the blood pressure and erythrocyte membrane fluidity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Membrane fluidity was assessed using spin labeling technique and electron paramagnetic resonance (EPR) spectroscopy. Two different spin labels were used in this study, 5-doxylstrearic acid (5-SASL) and 16-doxylstearic acid (16-SASL). The rats were given vitamin E, 3 days/week for 3 weeks and blood pressure was measured once weekly, using the tail-cuff method. Subsequently, blood was taken via heart puncture and erythrocytes were prepared for spin labeling. The fluidity of the membrane in the nonpolar region of erythrocytes from hypertensive rats was found quite different from that of normal rats as judged by the spectra of 16-SASL. The values of maximum splitting parameter of the EPR spectra of the spin label 5-SASL incorporated in erythrocyte membrane from both SHR and WKY rats, and the effects of vitamin E on membrane fluidity were compared. The maximum splitting parameter calculated from EPR spectra was larger for SHR than WKY rats. Additionally, the maximum splitting parameter calculated for vitamin E treated SHR and WKY rats were lower than those of their respective controls. As expected, the blood pressure of the SHR rats was found to be higher than that of the WKY rats. Vitamin E treated SHR and WKY rats showed significantly lower blood pressure than their controls, (C) 2000 Elsevier Science Inc. All rights reserved. [References: 30]
机译：发现维生素E治疗可降低血压，并增加大鼠的膜流动性。这项研究的目的是研究抗氧化剂维生素E对自发性高血压（SHR）和血压正常（WKY）大鼠的血压和红细胞膜流动性的影响。使用自旋标记技术和电子顺磁共振（EPR）光谱评估膜的流动性。在这项研究中使用了两种不同的自旋标记物，即5-doxyl硬脂酸（5-SASL）和16-doxyls硬脂酸（16-SASL）。每周3天/天，连续3周给大鼠服用维生素E，并使用尾套法每周测量一次血压。随后，通过心脏穿刺取血，并准备红细胞用于旋转标记。通过16-SASL的光谱判断，发现高血压大鼠红细胞非极性区域中膜的流动性与正常大鼠完全不同。比较了SHR和WKY大鼠红细胞膜中掺入的自旋标记物5-SASL的EPR谱的最大分裂参数值，以及维生素E对膜流动性的影响。从SPR的EPR光谱计算得出的最大分裂参数比WKY大鼠更大。此外，为维生素E治疗的SHR和WKY大鼠计算的最大分裂参数低于其各自对照的最大分裂参数。正如预期的那样，发现SHR大鼠的血压高于WKY大鼠的血压。维生素E治疗的SHR和WKY大鼠的血压明显低于其对照组，（C）2000 Elsevier Science Inc.保留所有权利。 [参考：30]

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