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首页> 外文期刊>Life sciences >A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis
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A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis

机译：角叉菜胶诱发的单关节炎后阿司匹林长期暴露于阿司匹林对炎症，痛觉过敏和开放视野活动的比较

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The purpose of the present study was to investigate whether chronic aspartame exposure possesses analgesic and anti-inflammatory actions in the carrageenan-induced monoarthritis model similar to those properties of aspirin. Prior research demonstrated that aspartame can reduce second phase formalin pain and increase motor activity in arthritic patients. Fifty-eight male Sprague-Dawly rats were treated with aspartame (25, 50, 100 mg/kg) or saline for six days. An additional group of animals received daily injections of saline and on the sixth treatment day, received a 150-mg/kg dose of aspirin 30-minutes prior to behavioral testing. On Day 6, animals received an intra-articular (i.a.) injection of 2% lambda carrageenan (CARR) or an equal volume of saline and were tested four hours later on threshold to mechanical and thermal stimuli, open field activity, and knee joint diameter. Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals. However, aspirin did not reverse thermal hyperalgesia or increase motor activity to control levels. Aspartame did not reduce inflammation, increase motor activity, or attenuate thermal allodynia, but at 50 mg/kg did attenuate mechanical allodynia compared with vehicle treated arthritic animals. The anti-hyperalgesic effect on mechanical hyperalgesia was not seen at 25 mg/kg or 100 mg/kg aspartame. These results suggest that a certain amount of aspartame may provide relief of arthritic pain to a similar degree as aspirin in some individuals. The specific effect of aspartame and aspirin on mechanical hyperalgesia should be considered when these agents are used for the therapeutic treatment of arthritic conditions. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 31]
机译：本研究的目的是调查在角叉菜胶诱发的单关节炎模型中，与阿司匹林的那些特性相似，长期暴露于阿斯巴甜中是否具有镇痛和抗炎作用。先前的研究表明，阿斯巴甜可以减轻关节炎患者的第二阶段福尔马林疼痛并增加运动能力。 58只雄性Sprague-Dawly大鼠用阿斯巴甜（25、50、100 mg / kg）或生理盐水处理六天。另一组动物每天接受盐水注射，并在第六个治疗日在行为测试前30分钟接受150 mg / kg剂量的阿司匹林。在第6天，动物接受了2％λ角叉菜胶（CARR）或等量生理盐水的关节内（ia）注射，并在4小时后接受了机械和热刺激，开放视野活动和膝关节直径的阈值测试。与媒介物治疗的关节炎动物相比，阿司匹林治疗的关节炎动物表现出明显更少的机械性痛觉过敏和膝关节发炎。但是，阿司匹林并未逆转热痛觉过敏或增加运动能力至控制水平。阿斯巴甜不会减轻炎症，增加运动活性或减轻热痛觉过敏，但与媒介物治疗的关节炎动物相比，以50 mg / kg的剂量阿司匹林确实能减轻机械痛觉过敏。在25 mg / kg或100 mg / kg阿斯巴甜中未观察到对机械性痛觉过敏的抗痛觉过敏作用。这些结果表明，在某些个体中一定量的阿斯巴甜可以减轻关节炎的疼痛，其程度与阿司匹林相似。当这些药物用于关节炎疾病的治疗时，应考虑阿斯巴甜和阿司匹林对机械性痛觉过敏的特定作用。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：31]

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