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The H-3 receptor is involved in cholecystokinin inhibition of food intake in rats

机译：H-3受体参与胆囊收缩素对大鼠食物摄入的抑制作用

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We investigated the peripheral effects of an H-3-receptor agonist and an H-3-receptor antagonist (R)alpha -methylhistamine (R alpha -MeHA) and thioperamide, respectively, on basal feeding and the CCK8-induced inhibition of food intake in rat. Intraperitoneal injection of thioperamide reduced food intake in a dose-dependent manner with maximal inhibition (35%, P<0.01 vs saline) at 3 mg/kg. (R)-MeHA (0.3-3 mg/kg i.p.), an H-3-receptor agonist alone had no effect on feeding but reversed the thioperamide-induced inhibition of food intake in a dose-dependent manner. The maximal feeding inhibitory dose of thioperamide (3 mg.kg i.p) increased by 40% and 22% (P<0.01 vs saline) brain and stomach histamine contents, respectively. Histamine (0.3-6 mg/kg i.p.) and CCK-8 (3-30 g/kg i.p) also inhibited food intake in a dose-dependent manner. Inhibition was 20% to 40% for histamine and 40% to 80% (P<0.01 vs saline) for CCK8. CCK-8 inhibition of feeding was increased by thioperamide and prevented by (R)-MeHA in a dose-dependent way. In addition, CCK-8 did not reduce food intake if rats were pretreated with pyrilamine or ranitidine postsynaptic H-1- and H-2-receptor antagonists respectively. Our data suggest that the H-3-receptor is involved in basal feeding. They also suggest that CCK satiety depends upon the release of histamine which acts on the H-2- and H-1-receptors, the final mediators of this effect. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 47]
机译：我们研究了H-3-受体激动剂和H-3-受体拮抗剂（R）α-甲基组胺（R alpha -MeHA）和硫代过酰胺对基础喂养和CCK8诱导的食物摄取抑制的外围作用在老鼠腹膜内注射硫代过酰胺以3毫克/千克的剂量依赖性最大程度地抑制（35％，P <0.01 vs盐水），以剂量依赖性方式减少食物摄入。单独的H-3-受体激动剂（R）-MeHA（0.3-3mg / kg i.p.）对喂养没有影响，但是以剂量依赖性方式逆转了硫代​​过酰胺诱导的食物摄取抑制。硫代过酰胺的最大摄食抑制剂量（3 mg.kg i.p）分别增加了脑和胃中组胺含量的40％和22％（与盐水相比，P <0.01）。组胺（0.3-6mg / kg i.p.）和CCK-8（3-30μg/ kg i.p.）也以剂量依赖性方式抑制食物摄入。组胺的抑制率为20％至40％，CCK8的抑制率为40％至80％（P <0.01，相对于盐水）。硫代过酰胺增强了对CCK-8的进食抑制作用，而（R）α-MeHA以剂量依赖的方式阻止了对CKK-8进食的抑制。另外，如果分别用吡拉明或雷尼替丁突触后H-1-和H-2-受体拮抗剂预处理大鼠，CCK-8不会减少食物摄入。我们的数据表明，H-3-受体参与了基础喂养。他们还表明，CCK饱腹感取决于组胺的释放，该组胺作用于这种作用的最终介导物H-2-和H-1受体。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：47]

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