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首页> 外文期刊>Life sciences >Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity
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Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting Fos-related antigen-immunoreactivity

机译：右美沙芬同时影响可卡因介导的行为模式和持久的Fos相关抗原免疫反应

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摘要

In order to understand the underlying mechanisms responsible for the behaviors mediated by dextromethorphan (DM),we examined the effects of DM on locomotor activity and locomotor patterns in mice, and Fos-related antigen immunoreactivity (ERA-IR) of mouse brain following repeated administration of cocaine. Combined treatments (30 min prior to each cocaine administration) with DM dose-dependently decreased locomotor activity for high doses of cocaine (20 mg/icg, i.p./day x 7). DM combinations did not significantly affect hyperactivity for 10 mg cocaine/kg, i.p./day x 7, In contrast, combined treatments with DM increased the locomotor activity for 5 mg cocaine/kg, i.p./day x 7. These results were consistent with alterations in marginal activity. Repeated administration with cocaine or DM increased FRA-IR in the nucleus accumbens (NAc) and striatum which lasted for at least 7 days. Our results suggest that DM exhibits biphasic effects on the locomotor stimulation induced by cocaine, and that locomotor activities are in parallel with FRA-IR of the striatal complex. However, the role of FRA-IR regulated by DM or/and cocaine remains to be further determined. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 30]
机译：为了了解负责右美沙芬（DM）介导的行为的潜在机制，我们研究了DM对重复给药后DM对小鼠运动能力和运动模式以及小鼠大脑Fos相关抗原免疫反应性（ERA-IR）的影响可卡因。高剂量可卡因的联合治疗（每次可卡因给药前30分钟）与DM剂量依赖性地降低了运动活性（20 mg / icg，腹膜内/天x 7）。 DM组合对于10 mg可卡因/ kg，腹腔注射/天x 7不会明显影响机能亢进。相比之下，DM联合治疗对5 mg可卡因/ kg，腹腔注射/天x 7的运动活动增加。这些结果与改变相符在边缘活动中。重复施用可卡因或DM可增加伏隔核（NAc）和纹状体中的FRA-1R，持续至少7天。我们的结果表明，DM对可卡因引起的运动刺激具有双相作用，并且运动活性与纹状体复合物的FRA-IR平行。然而，由DM或/和可卡因调节的FRA-IR的作用仍有待进一步确定。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：30]

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