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首页> 外文期刊>Cell and Tissue Research >Hippo pathway/Yap regulates primary enamel knot and dental cusp patterning in tooth morphogenesis
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Hippo pathway/Yap regulates primary enamel knot and dental cusp patterning in tooth morphogenesis

机译：河马通路/ Yap调节牙釉质形成过程中的初级牙釉质结和牙尖形态

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摘要

The shape of an individual tooth crown is primarily determined by the number and arrangement of its cusps, i.e., cusp patterning. Enamel knots that appear in the enamel organ during tooth morphogenesis have been suggested to play important roles in cusp patterning. Animal model studies have shown that the Hippo pathway effector Yap has a critical function in tooth morphogenesis. However, the role of the Hippo pathway/Yap in cusp patterning has not been well documented and its specific roles in tooth morphogenesis remain unclear. Here, we provide evidence that Yap is a key mediator in tooth cusp patterning. We demonstrate a correlation between Yap localization and cell proliferation in developing tooth germs. We also show that, between the cap stage and bell stage, Yap is crucial for the suppression of the primary enamel knot and for the patterning of secondary enamel knots, which are the future cusp regions. When Yap expression is stage-specifically knocked down during the cap stage, the activity of the primary enamel knot persists into the bell-stage tooth germ, leading to ectopic cusp formation. Our data reveal the importance of the Hippo pathway/Yap in enamel knots and in the proper patterning of tooth cusps.
机译：单个牙冠的形状主要由其牙尖的数量和布置即牙尖构图确定。牙齿形态发生过程中出现在牙釉质器官中的牙釉质结被认为在牙尖形态中起重要作用。动物模型研究表明，Hippo通路效应器Yap在牙齿形态发生中起关键作用。然而，河马途径/ Yap在牙尖模式中的作用尚未得到充分的证明，其在牙齿形态发生中的具体作用仍不清楚。在这里，我们提供的证据表明Yap是牙尖构图的关键介体。我们证明了Yap本地化和发展中的牙胚细胞增殖之间的相关性。我们还表明，在顶盖阶段和钟形阶段之间，Yap对于压制主要的牙釉质结和对作为未来风口的次要牙釉质结的图案至关重要。当Yap的表达在帽形阶段被阶段特异性地敲低时，初级釉质结的活性持续到钟形阶段的牙胚中，导致异位牙尖的形成。我们的数据揭示了在釉质结和正确的牙尖图案中，Hippo通路/ Yap的重要性。

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