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首页> 外文期刊>Life sciences >Kava-kava and anxiety: growing knowledge about the efficacy and safety.
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Kava-kava and anxiety: growing knowledge about the efficacy and safety.

机译：卡瓦卡瓦和焦虑：关于功效和安全性的知识不断增长。

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摘要

Kava-kava (Piper methysticum G. Forster) has been used in social and ceremonial life in the Pacific islands from ancient times for the soporific and narcotic effects. Today several extracts standardized in the biologically active constituents kavalactones are marketed both as herbal medicinal products for anxiety disorders and as dietary supplements to improve stress disorders, nervous tension and restlessness. Unlike other substances used for these purposes, kava-kava has been shown to have minimal negative effects, and possibly positive effects, on reaction time and cognitive processing. Furthermore, it decreases anxiety without the loss of mental acuity. Although kava-kava has been found to be very effective, well tolerated, and non-addictive at therapeutic dosages, potential side effects can occur when very high doses are taken for extended periods. In addition, in the last two years unexpected high liver toxicity has been reported in two patients. Until now no studies support the liver toxicity of kavalactones and it is unknown which compound could have provoked the liver disease. On the other hand, it should be possible that unknown or unexpected constituents are the responsible or contributed to the liver toxicity.
机译：卡瓦卡瓦（Piper methysticum G. Forster）自古以来就已在太平洋诸岛的社交和礼仪生活中使用，具有蜂鸣和麻醉作用。如今，几种标有生物活性成分卡伐内酯的提取物既可以作为治疗焦虑症的草药产品，也可以作为改善压力障碍，神经紧张和躁动的饮食补品。与用于这些目的的其他物质不同，卡瓦-卡瓦已被证明对反应时间和认知过程具有最小的负面影响，甚至可能是正面影响。此外，它可以减少焦虑而不会失去智力。尽管已发现卡瓦卡瓦在治疗剂量下非常有效，耐受性好且不易上瘾，但如果长期服用非常高剂量的卡瓦-卡瓦，可能会出现副作用。另外，在过去的两年中，已经报道了两名患者意外的高肝毒性。迄今为止，尚无任何研究支持卡伐内酯的肝毒性，尚不清楚哪种化合物可能引起肝病。另一方面，未知或意外的成分可能是肝脏毒性的原因或原因。

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