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首页> 外文期刊>Cell and Tissue Research >Evolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system
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Evolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system

机译：将基因调控网络发展为指导适应性行为的细胞网络：概述单细胞如何演变为集中式神经感觉系统

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Understanding the evolution of the neurosensory system of man, able to reflect on its own origin, is one of the major goals of comparative neurobiology. Details of the origin of neurosensory cells, their aggregation into central nervous systems and associated sensory organs and their localized patterning leading to remarkably different cell types aggregated into variably sized parts of the central nervous system have begun to emerge. Insights at the cellular and molecular level have begun to shed some light on the evolution of neurosensory cells, partially covered in this review. Molecular evidence suggests that high mobility group (HMG) proteins of pre-metazoans evolved into the definitive Sox [SRY (sex determining region Y)-box] genes used for neurosensory precursor specification in metazoans. Likewise, pre-metazoan basic helix-loop-helix (bHLH) genes evolved in metazoans into the group A bHLH genes dedicated to neurosensory differentiation in bilaterians. Available evidence suggests that the Sox and bHLH genes evolved a cross-regulatory network able to synchronize expansion of precursor populations and their subsequent differentiation into novel parts of the brain or sensory organs. Molecular evidence suggests metazoans evolved patterning gene networks early, which were not dedicated to neuronal development. Only later in evolution were these patterning gene networks tied into the increasing complexity of diffusible factors, many of which were already present in pre-metazoans, to drive local patterning events. It appears that the evolving molecular basis of neurosensory cell development may have led, in interaction with differentially expressed patterning genes, to local network modifications guiding unique specializations of neurosensory cells into sensory organs and various areas of the central nervous system.
机译：了解人类的神经感觉系统的进化，能够反思其起源，是比较神经生物学的主要目标之一。关于神经感觉细胞的起源，它们聚集到中枢神经系统和相关的感觉器官以及它们的局部模式的详细信息已经开始出现，这些模式导致明显不同的细胞类型聚集到中枢神经系统大小各异的部分中。在细胞和分子水平上的洞察力已开始为神经感觉细胞的进化提供一些启示，本综述对此进行了部分介绍。分子证据表明，前metazoans的高迁移率族（HMG）蛋白演变成确定的Sox [SRY（性别决定区域Y）-box]基因，用于后生动物的神经感觉前体规范。同样，前metazoan基本螺旋-环-螺旋（bHLH）基因在后生动物中进化成A组bHLH基因，专门用于在双边生物中进行神经感觉分化。现有证据表明，Sox和bHLH基因形成了一个交叉调控网络，能够使前体种群的扩展及其随后分化为大脑或感觉器官的新部分同步化。分子证据表明，后生动物早期进化了模式基因网络，但并不致力于神经元发育。直到进化的后期，这些模式基因网络才与不断增加的扩散因子的复杂性联系在一起，其中许多因素已经存在于前metazoans中，以驱动局部模式事件。看起来，神经感觉细胞发育的不断发展的分子基础可能与差异表达的模式基因相互作用，导致了局部网络修饰，从而将神经感觉细胞的独特专长引导到感觉器官和中枢神经系统的各个区域。

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