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首页> 外文期刊>Cell and Tissue Research >Arrested development of the dorsal column following neonatal spinal cord injury in the opossum, Monodelphis domestica
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Arrested development of the dorsal column following neonatal spinal cord injury in the opossum, Monodelphis domestica

机译：负鼠新生鼠脊髓损伤后背柱发育受阻

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摘要

Developmental studies of spinal cord injury in which regrowth of axons occurs across the site of transection rarely distinguish between the recovery of motor-controlling pathways and that of ascending axons carrying sensory information. We describe the morphological changes that occur in the dorsal column (DC) of the grey short-tailed opossum, Monodelphis domestica, following spinal cord injury at two early developmental ages. The spinal cords of opossums that had had their mid-thoracic spinal cords completely transected at postnatal day 7 (P7) or P28 were analysed. Profiles of neurofilament immunoreactivity in transected cords showing DC development were differentially affected by the injury compared with the rest of the cord and cytoarchitecture was modified in an age- and site-dependent manner. The ability of DC neurites to grow across the site of transection was confirmed by injection of fluorescent tracer below the injury. P7 transected cords showed labelling in the DC above the site of original transection indicating that neurites of this sensory tract were able to span the injury. No growth of any neuronal processes was seen after P28 transection. Thus, DC is affected by spinal injury in a differential manner depending on the age at which the transection occurs. This age-differential response, together with other facets of remodelling that occur after neonatal spinal injury, might explain the locomotor adaptations and recovery observed in these animals.
机译：脊髓损伤的发展研究中，轴突的再生贯穿整个横断部位，很少区分运动控制途径的恢复和携带感觉信息的轴突的恢复。我们描述了在两个早期发育年龄的脊髓损伤后，灰色短尾负鼠，Monodelphis domestica的背柱（DC）中发生的形态变化。分析在出生后第7天（P7）或P28完全切开了它们的胸中脊髓的负鼠脊髓。与其他脊髓相比，横断脊髓的神经丝免疫反应性表现出DC发育受损伤的影响不同，并且细胞结构以年龄和部位依赖性方式被修饰。通过在损伤下方注射荧光示踪剂证实DC神经突在横切部位生长的能力。 P7横断的脐带在原始横断部位上方的DC中显示标签，表明该感觉通道的神经突能够跨越损伤。 P28横切后未见任何神经元进程的生长。因此，取决于横断发生的年龄，DC以不同的方式受到脊柱损伤的影响。这种年龄差异反应以及新生脊髓损伤后发生的其他重塑方面可能解释了这些动物的运动适应性和恢复能力。

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