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Favorable and unfavorable lactation modulates the effects of electrical stimulation on brain excitability: A spreading depression study in adult rats

机译：有利和不利的泌乳调节电刺激对脑兴奋性的影响：成年大鼠的抑郁症扩散研究

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Aims: We investigated how different nutritional states resulting from distinct lactation conditions modulate the effects of cortical electrical stimulation (CES) on the excitability-related phenomenon known as cortical spreading depression (CSD). Main methods: Wistar rats were reared in different litter sizes with 12, 6 or 3 pups, designated as malnourished (M), well-nourished (W) and overnourished (Ov), respectively. CSD was recorded for 4 h on 2 cortical points of each cerebral hemisphere at baseline and after CES. CES was applied for 20 min on the left cortex using a bipolar electrode placed between the CSD recording electrodes. Paired Student t test and ANOVA followed by Tukey test were used for statistical analysis (p < 0.05). Key findings: The lactation conditions significantly influenced body weight (the M and Ov groups presented the lowest and largest average weight, respectively) and modified the CSD velocities of propagation in adulthood (Ov < W < M CSD velocity). CES increased CSD velocity of propagation in the stimulated hemisphere in all groups, and in the non-stimulated hemisphere (8.66% ± 1.38) in the Ov group only. We observed nutritional-dependent CES effects on cortical excitability as evaluated by the different CSD velocities across the three groups (mean ± sem, M (10.13% ± 1.70), Ov (14.65% ± 1.10) and W (25.70% ± 5.05)). Significance: These findings suggest valuable mechanisms of action for the brain stimulation techniques, which have gained importance because of their increasing use for the treatment of neuropsychiatric diseases. Data also suggest modulation of CES-effects by baseline excitability (as determined by the early nutritional state).
机译：目的：我们研究了由不同的泌乳条件导致的不同营养状态如何调节皮质电刺激（CES）对与兴奋性相关的现象（称为皮质扩散抑制（CSD））的影响。主要方法：Wistar大鼠以12，6或3只幼崽大小不同地饲养，分别指定为营养不良（M），营养良好（W）和营养过度（Ov）。在基线和CES之后，在每个脑半球的2个皮质点记录4小时的CSD。使用位于CSD记录电极之间的双极电极，在左侧皮层上应用CES 20分钟。使用成对的学生t检验和ANOVA，然后进行Tukey检验进行统计学分析（p <0.05）。主要发现：泌乳条件显着影响体重（M组和Ov组分别代表最低和最大平均体重），并改变了成年后CSD的传播速度（Ov

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