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首页> 外文期刊>Life sciences >INCREASED CARTILAGE AND BONE FORMATION IN SPONTANEOUSLY HYPERCHOLESTEROLEMIC RATS
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INCREASED CARTILAGE AND BONE FORMATION IN SPONTANEOUSLY HYPERCHOLESTEROLEMIC RATS

机译：自发性高胆固醇血症大鼠的软骨和骨形成增加

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Spontaneously hypercholesterolemic (SHC) rats are known to exhibit accelerated bone resorption. We compared endochondral bone formation induced by implantation of demineralized bone matrix (DBM) to 4-week-old SHC rats with that of age-matched Sprague-Dawley (SD) rats. When DBM prepared from adult SD rats was implanted, the cartilageous area enlarged, and C-propeptide of type II procollagen content on day 7 was higher in SHC rats. Alkaline phosphatase activity and calcium content on day 12 and tartrate-resistant acid phosphatase activity on day 19 were higher in SHC rats. These results suggest active chondrogenesis, with a subsequent increase in osteogenesis, and stimulated osteoclastic bone resorption in SHC rats. When DBM from 10-week-old SHC rats was implanted into SD or SHC rats, the levels of bone forming parameters on day 12 were reduced to one-third, suggesting inhibiting factor(s) for bone induction in bone matrix of SHC rats. In contrast, when DBM from 6-month-old SHC rats was implanted, although bone forming parameters in SD rats were comparable to the case of implantation of DBM from SD rats, the accelerated bone formation detected in SHC rats was blocked, indicating resistance to systemic bone inducing factor(s) of SHC rats in aged bone matrix. These results suggest that age-related decrease in responses to some systemic bone inducing factor may lead to the bone loss with advancing age. [References: 21]
机译：已知自发性高胆固醇血症（SHC）大鼠表现出加速的骨吸收。我们比较了与年龄匹配的Sprague-Dawley（SD）大鼠相比，向4周龄SHC大鼠植入脱矿质骨基质（DBM）诱导的软骨内骨形成。当植入由成年SD大鼠制备的DBM时，SHC大鼠的软骨区域扩大，并且在第7天，II型胶原蛋白的C-肽含量更高。在SHC大鼠中，第12天的碱性磷酸酶活性和钙含量以及第19天的抗酒石酸酸性磷酸酶活性较高。这些结果表明，活跃的软骨形成，继而增加了成骨作用，并刺激了SHC大鼠的破骨细胞吸收。当将来自10周龄SHC大鼠的DBM植入SD或SHC大鼠中时，第12天的骨形成参数水平降低至三分之一，这表明SHC大鼠骨基质中的骨诱导抑制因子。相反，当植入6个月大SHC大鼠的DBM时，尽管SD大鼠的骨形成参数与从SD大鼠植入DBM的情况相当，但SHC大鼠中检测到的加速骨形成被阻止，表明对老年骨基质中SHC大鼠的全身性骨诱导因子这些结果表明，随着年龄的增长，对某些全身性骨诱导因子的反应下降可能导致骨质流失。 [参考：21]

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