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MARIJUANA INTOXICATION AND BRAIN ACTIVATION IN MARIJUANA SMOKERS

机译：里约热内卢吸烟者对里约热内的毒化和脑活化

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Objective and Method: The acute effects of delta(9) tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with O-15-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exposure to marijuana. Scans were performed before and after intravenous (IV) infusion of either of two doses of THC or a placebo, given under double blind conditions. Results: THC but not placebo increased CBF especially in the frontal regions bilaterally, insula and cingulate gyrus and sub-cortical regions with somewhat greater effects in the right hemisphere. While most regions showed significant change at 60 minutes for the lower dose group, the higher dose group had significant change at 30 and 60 minutes. There was a highly significant change in the anterior/posterior ratio for the two THC groups reflecting minimal change in occipital flow but significant increases in frontal flow. Self ratings of THC intoxication showed significant effects, and regression analysis indicated it correlated most markedly with the right frontal region. Conclusion: Behavioral manifestations of marijuana intoxication may be associated with increased functional activity of the brain especially the frontal cortex, insula and cingulate gyrus. [References: 67]
机译：目的和方法：研究了人类受试者中delta（9）四氢大麻酚（THC）对脑血流量（CBF）的急性影响。使用O-15水和正电子发射断层扫描（PET）在32名有大麻暴露史的志愿者中测量了区域CBF。在双盲条件下，在静脉（IV）输注两种剂量的THC或安慰剂之前和之后进行扫描。结果：THC而不是安慰剂可增加CBF，尤其是在双侧额叶，岛状和扣带回以及皮质下区域，其右半球的影响更大。对于低剂量组，大多数区域在60分钟时有明显变化，而高剂量组在30分钟和60分钟时有显着变化。两个THC组的前/后比有非常显着的变化，反映了枕叶流量的最小变化，但额叶流量的显着增加。 THC醉酒的自我评价显示出显着效果，回归分析表明它与右额叶区域最显着相关。结论：大麻中毒的行为表现可能与大脑的功能活动增加有关，尤其是额叶皮层，绝缘体和扣带回。 [参考：67]

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