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首页> 外文期刊>Life sciences >Seasonal effects of rotational stress on Lewis lung carcinoma metastasis and T-lymphocyte subsets in mice.
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Seasonal effects of rotational stress on Lewis lung carcinoma metastasis and T-lymphocyte subsets in mice.

机译：旋转应激对小鼠Lewis肺癌转移和T淋巴细胞亚群的季节性影响。

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摘要

Rotational stress specifically increases the formation of spontaneous lung metastasis in mice bearing Lewis lung carcinoma, without significantly modifying the growth of primary tumor. The increase in metastasis number and volume caused by rotational stress varies in magnitude with a highly significant circannual rhythm; the acrophase approximately coincides with summer solstice. Rotational stress causes a significant reduction in the number of CD3+ and CD4+ T-lymphocyte subsets in summer, whereas in winter the number of CD3+ subset is significantly increased; the CD4+/CD8+ ratio and the number of NK 1.1 antigen positive cells are not significantly modified by rotational stress in both periods considered. The increase in metastasis formation by rotational stress thus appears to negatively correlate with the number of splenic CD3+ and CD4+ T-lymphocyte subsets. This seasonal behavior occurs in spite of the control of light cycle, temperature and humidity in the animal housing, suggesting the existence in the host of an endogenous oscillator with a circannual period. These data indicate the opportunity to consider endogenous rhythms within the host, as well as seasonal factors, in studies on stress and neuroimmunomodulation in experimental oncology.
机译：旋转应力在不明显改变原发性肿瘤生长的情况下，特别增加了携带Lewis肺癌的小鼠自发性肺转移的形成。由旋转应力引起的转移数量和体积的增加幅度变化很大，并具有明显的昼夜节律;顶相与夏至大致重合。旋转应力在夏天导致CD3 +和CD4 + T淋巴细胞亚群的数量显着减少，而在冬天，CD3 +亚群的数量显着增加。在所考虑的两个时期中，旋转压力均未显着改变CD4 + / CD8 +比率和NK 1.1抗原阳性细胞的数量。因此，由旋转应力引起的转移形成的增加似乎与脾脏CD3 +和CD4 + T淋巴细胞亚群的数量负相关。尽管控制了动物舍内的光周期，温度和湿度，但这种季节性行为仍然发生，这表明宿主体内存在一个具有周期性的内生振荡器。这些数据表明在实验性肿瘤学中对应激和神经免疫调节的研究中，有机会考虑宿主内源性节律以及季节性因素。

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