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首页> 外文期刊>Life sciences >Role of nitric oxide in exercise-induced vasodilation in man.
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Role of nitric oxide in exercise-induced vasodilation in man.

机译：一氧化氮在人体运动诱发的血管舒张中的作用。

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摘要

Nitric oxide (NO) is a potent endothelium-derived vasodilator, which is known to play an important role in the regulation of resting vascular tone in animals and humans. However, the degree to which NO is involved in exercise-induced vasodilation in the skeletal muscle remains unclear. We studied the effect of N-monomethyl-L-arginine (L-NMMA) in a randomized, double-blind, placebo controlled cross over study in 16 young, healthy volunteers ( 8 male, 8 female) at rest and during bicycle exercise stress test. L-NMMA was given as a bolus of 3 mg/kg over 5 minutes followed by a continuous i.v. infusion of 50 microg/kg/min over 75 minutes. Subjects underwent a symptom-limited graded bicycle stress test with a 25 Watt increase in workload every 5 minutes. Skin and muscle blood flow were measured by laser Doppler flowmetry. L-NMMA slightly increased mean arterial blood pressure and decreased NO exhalation, but had no effect on pulse rate, oxygen consumption (VO2), skin or muscle blood flow at rest. Moreover, L-NMMA exerted no effect on exercise-induced changes in hemodynamics. Our results suggest that submaximal inhibition of NO-synthase with L-NMMA at doses that induce moderate hemodynamic changes does not affect exercise induced vasodilation.
机译：一氧化氮（NO）是一种有效的内皮源性血管舒张剂，已知在调节动物和人类的静息血管张力中起重要作用。但是，目前尚不清楚骨骼肌中NO参与运动诱导的血管舒张的程度。我们研究了N-单甲基-L-精氨酸（L-NMMA）在一项随机，双盲，安慰剂对照的交叉研究中对16名健康的年轻志愿者（8名男性，8名女性）在休息和骑自行车运动过程中的压力的​​影响。测试。在5分钟内以3 mg / kg的大剂量推注L-NMMA，然后连续静脉内注射。在75分钟内输注50 microg / kg / min。受试者进行了症状受限的分级自行车压力测试，每5分钟增加25瓦的工作量。通过激光多普勒血流仪测量皮肤和肌肉的血流。 L-NMMA略微增加了平均动脉血压，降低了NO呼气，但对静息时的脉搏率，耗氧量（VO2），皮肤或肌肉血流没有影响。此外，L-NMMA对运动引起的血液动力学变化没有影响。我们的结果表明，在诱导中度血流动力学改变的剂量下，L-NMMA对NO合酶的抑制作用最大，不会影响运动引起的血管舒张。

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