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首页> 外文期刊>Life sciences >Aromatase and testosterone receptor in the liver of the female green frog, Rana esculenta.
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Aromatase and testosterone receptor in the liver of the female green frog, Rana esculenta.

机译：雌蛙蛙的肝脏中的芳香酶和睾丸激素受体。

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In the green frog, Rana esculenta, a peculiar feature of female reproductive endocrinology is an high level of circulating testosterone. Although several hypotheses have been set out to explain this phenomenon, the testosterone specific roles in female anuran have not been yet fully explored. This study results propose a testosterone implication in liver vitellogenin synthesis control, since in ovariectomized frogs the hormone induces an increase of circulating vitellogenin. The testosterone action could depend on its local conversion to 17beta-estradiol by aromatase which is present in frog liver tissue. Liver aromatase activity ranges from 7.5 to 26 fmoles E2 formed/mg protein/h and results higher as long as liver is engaged in vitellogenin synthesis. Aromatase activity seems depend on testosterone since it decreases after ovariectomy and is restored by testosterone injection in ovariectomized frogs. In green frog liver, testosterone binding molecules are present both in cytosol and nuclei. These molecule binding properties (Kd and Bmax in nM range; t 1/2 = 85 min; specificity) are in line with those of testosterone receptor of other lower vertebrate target tissue. In liver nuclei, testosterone receptor level undergoes modification throughout the sexual cycle which almost coincides with that of plasma testosterone level and liver aromatase activity. This could indicate that the testosterone induction of liver aromatase in frogs is via the testosterone receptor, as reported for aromatase of mammalian brain tissues.
机译：在绿色青蛙中，雌性生殖内分泌学的一个特殊特征是蛙蛙（Rana esculenta），其循环睾丸激素水平很高。尽管已经提出了几种假说来解释这种现象，但尚未充分探讨雌性阿努兰中睾丸激素的特定作用。这项研究结果表明睾丸激素在肝脏卵黄蛋白原合成控制中具有重要意义，因为在去卵巢的青蛙中，激素会诱导循环卵黄蛋白原增加。睾丸激素的作用可能取决于其在蛙肝组织中存在的芳香化酶向17β-雌二醇的局部转化。肝芳香化酶的活性范围为7.5至26 fmoles E2 / mg蛋白/ h，只要肝脏参与卵黄蛋白原合成，结果就更高。芳香酶活性似乎取决于睾丸激素，因为它在卵巢切除术后会降低，并通过切除卵巢的青蛙体内的睾丸激素注射而恢复。在绿色青蛙肝脏中，睾丸激素结合分子同时存在于细胞质和细胞核中。这些分子结合特性（Kd和Bmax在nM范围内; t 1/2 = 85分钟;特异性）与其他较低脊椎动物靶组织的睾丸激素受体的结合特性一致。在肝细胞核中，睾丸激素受体水平在整个性周期中都会发生变化，这几乎与血浆睾丸激素水平和肝芳香酶活性相吻合。这可能表明青蛙的肝脏芳香化酶的睾丸激素诱导作用是通过睾丸激素受体实现的，正如哺乳动物脑组织的芳香化酶报道的那样。

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