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Role of endothelin B receptor signals in reactive astrocytes.

机译:内皮素B受体信号在星形胶质细胞中的作用。

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We investigated the involvement of endothelinB receptor signals in the activation of astrocytes in vitro and in vivo. Endothelin reversed the stellate morphology of astrocytes induced by several agents. Endothelin stimulates astrocytic stress fiber formation. This effect of endothelin is Ca2+-independent and mediated by rho protein signal cascades linked to tyrosine phosphorylation. Injection of endothelin into striatum caused reactive astrocytosis which is prevented by a systemic injection of endothelinB receptor antagonist. We propose the role of endothelinB receptor signal transduction in reactive astrocytes.
机译:我们调查了内皮素B受体信号参与体外和体内星形胶质细胞的激活。内皮素逆转了几种药物诱导的星形胶质细胞的星状形态。内皮素刺激星形细胞应激纤维的形成。内皮素的这种作用是非Ca2 +依赖性的,并由与酪氨酸磷酸化有关的rho蛋白信号级联介导。将内皮素注射到纹状体中会引起反应性星形细胞增多,可通过全身性注射内皮素B受体拮抗剂来预防。我们提出内皮素B受体信号转导在反应性星形胶质细胞中的作用。

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