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首页> 外文期刊>Life sciences >Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance.
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Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance.

机译：Delta9-四氢大麻酚，但不是内源性大麻素受体配体阿南酰胺，会产生条件性避让。

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摘要

Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place conditioning task. Male Wistar rats received THC (0.0-8.0 mg/kg) or anandamide (0.0-16.0 mg/kg) during conditioning sessions. The half-life of anandamide was increased by pretreatment with the protease inhibitor phenylmethylsulfonyl fluoride (2.0 mg/kg). A significant place aversion was found at the 1.0 and 1.5 mg/kg doses of THC. No significant place conditioning effects were found with anandamide. Locomotor activity during conditioning was significantly decreased by the 1.0, 1.5, 2.0 and 4.0 mg/kg doses of THC as well as the 8.0 and 16.0 mg/kg doses of anandamide. These results fail to implicate the endogenous cannabinoid anandamide in reward-related learning or aversion.
机译：尽管外源性大麻素配体（例如delta9-四氢大麻酚（THC））与奖赏相关的学习和厌恶有关，但从未评估过内源性大麻素激动剂anandamide（花生四烯醇乙醇酰胺）的享乐效应。因此，在一个位置调节任务中测试了anandamide的作用。雄性Wistar大鼠在调理过程中接受THC（0.0-8.0 mg / kg）或anandamide（0.0-16.0 mg / kg）。通过用蛋白酶抑制剂苯基甲基磺酰氟（2.0 mg / kg）进行预处理，可以提高anandamide的半衰期。在1.0和1.5 mg / kg剂量的四氢大麻酚中发现了明显的厌恶感。 Anandamide没有发现明显的场所调节作用。分别以1.0、1.5、2.0和4.0 mg / kg剂量的THC以及8.0和16.0 mg / kg剂量的anandamide显着降低了调节期间的运动能力。这些结果未能暗示内源性大麻素大麻酚参与奖励相关的学习或厌恶。

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