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Systemic effects of ingested nickel on the immune system of nickel sensitised women.

机译：摄入镍对镍敏感女性免疫系统的全身影响。

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摘要

This study evaluates the immune response to ingestion of 10 mg of nickel (Ni) (as Ni sulphate) in 19 young non-atopic Ni-sensitised or 9 non-allergic women (group A). After Ni ingestion at 8 a.m, non-allergic and 12 Ni-sensitised women (group B) were non-symptomatic, while 7 Ni-sensitised women (group C) showed a flare up of urticaria and/or eczema. Serum and urine Ni were greatly lower before Ni administration than after 4 and 24 hours, without difference among the 3 groups. Before treatment, group B and C showed higher values of blood CD19+ and CD5--CD19+ cells than group A, while group C showed higher serum interleukin (IL) 2 and lower serum IL-5. Four hours after Ni ingestion, group C showed significant increase in serum IL-5. Twenty-four hours after treatment, group A showed a significant reduction in blood CD4+-CD45RO- "virgin" cells and an increase of CD8+ lymphocytes, while group C showed a marked decrease in total blood lymphocytes and CD3+, CD4+-CD45RO-, CD4+-CD45RO+, CD8+, CD19+ and CD5--CD19+ cell subsets. These data may be explained with migration of lymphocytes in tissues with a Th0-like immune response, as shown by the elevated serum IL-2 and the increase of serum IL-5 during the test.
机译：这项研究评估了19名年轻的非过敏性镍敏感青年或9名非过敏性妇女（A组）对摄入10毫克镍（硫酸镍）的免疫反应。上午8点摄入镍后，非过敏和12位镍致敏妇女（B组）无症状，而7位镍致敏妇女（C组）表现为荨麻疹和/或湿疹发作。服用Ni之前的血清和尿液Ni含量显着低于4和24小时后，这三组之间没有差异。治疗前，B组和C组的血液CD19 +和CD5--CD19 +细胞值均高于A组，而C组的血清白介素（IL）2较高，血清IL-5较低。镍摄入后四小时，C组显示血清IL-5明显升高。治疗后二十四小时，A组显示血液CD4 + -CD45RO-“原始”细胞显着减少，CD8 +淋巴细胞增加，而C组显示总血淋巴细胞和CD3 +，CD4 + -CD45RO-，CD4 +明显减少。 -CD45RO +，CD8 +，CD19 +和CD5--CD19 +细胞亚群。这些数据可以用具有Th0样免疫应答的组织中的淋巴细胞迁移来解释，如在测试过程中血清IL-2升高和血清IL-5升高所表明的。

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